Preston Marx

Preston Marx, PhD
Chair and Professor
Department of Tropical Medicine
Tulane University School of Public Health and Tropical Medicine
1440 Canal Street, Suite 2300
New Orleans, LA 70112
Phone: (504) 988-3558
Fax: (504) 988-7313

Dr. Preston Marx is holding the 2010 Discover Magazine Top 100 Scientific Achievements in which his Science article showing that the SIV family of viruses is hundreds of thousands of years older than previously believed was listed as number 20.

Research Interests:

  • Simian models for AIDS pathogenesis
  • HIV vaccines
  • Strategies for preventing HIV transmission to women

Educational Background:

  • BS, biology, University of New Orleans, New Orleans, LA
  • PhD, microbiology, Louisiana State University Medical Center, New Orleans, LA
  • Post-doctorate, virology, St. Jude's Children's Research Hospital, Memphis, TN

Professional Achievements:

  • 1987 Outstanding Research Achievement Award University of California Davis.
  • 1993-present Reviewer (selected list) - Science, Nature, PNAS, Journal of Virology, Vaccines, AIDS Research & Human Retroviruses, AIDS Journal, Nature Medicine
  • 1994-2001 Member, Aaron Diamond AIDS Research Center & Head of AIDS Animal Models Laboratory at TRPRC-Tulane University Medical Center, Covington, LA
  • 1998-2001 Member AIDS and Related Diseases Study Section NIAID
  • 1998-2001 Executive advisory board, Pediatric AIDS Foundation
  • 1998-present Core Scientist, Tulane University Health Sciences Center, Tulane National Primate Research Center, Division of Microbiology and Immunology, Covington, LA
  • 2000-2004 AIDS Research Advisory Committee (ARAC), NIH, NIAID, Bethesda, MD
  • 2005-present Editor-in-Chief, Journal of Medical Primatology

Selected Publications:

Hadzic SV, Wang X, Dufour J, Doyle L, Marx PA, Lackner AA, Paulsen DB, Veazey RS. (2014). Comparison of the Vaginal environment of Macaca mulatta and Macaca nemestrina Throughout the Menstrual Cycle. Am J Reprod Immunol. [Epub ahead of print]

Monjure CJ, Tatum CD, Panganiban AT, Arainga M, Traina-Dorge V, Marx PA, Didier ES. (2014). Optimization of PCR for quantification of simian immunodeficiency virus genomic RNA in plasma of rhesus macaques (Macaca mulatta) using armored RNA. J Med Primatol., 43(1), 31-43.

Veazey RS, Marx PA. (2013). The Symposium on Nonhuman Primate Models for AIDS. Introduction. J Med Primatol., 42(5), 229.

Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K, Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M Jr, Chertova E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF. (2013). Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies. J Virol., 87(8), 4584-95.

Reuter MA, Yuan S, Marx PA, Kutzler MA, Weiner DB, Betts MR. (2012). DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells. Hum Vaccin Immunother., 8(11), 1648-53.

Pahar B, Gray WL, Phelps K, Didier ES, deHaro E, Marx PA, Traina-Dorge VL. (2012). Increased cellular immune responses and CD4+ T-cell proliferation correlate with reduced plasma viral load in SIV challenged recombinant simian varicella virus - simian immunodeficiency virus (rSVV-SIV) vaccinated rhesus macaques. Virol J., 9, 160.

Wang J, Tricoche N, Du L, Hunter M, Zhan B, Goud G, Didier ES, Liu J, Lu L, Marx PA, Jiang S, Lustigman S. (2012). The adjuvanticity of an O. volvulus-derived rOv-ASP-1 protein in mice using sequential vaccinations and in non-human primates. PLoS One., 7(5), e37019.

Schell JB, Bahl K, Rose NF, Buonocore L, Hunter M, Marx PA, LaBranche CC, Montefiori DC, Rose JK. (2012). Viral vectored granulocyte-macrophage colony stimulating factor inhibits vaccine protection in an SIV challenge model: protection correlates with neutralizing antibody. Vaccine., 30(28), 4233-9.

Verreault D, Sivasubramani SK, Talton JD, Doyle LA, Reddy JD, Killeen SZ, Didier PJ, Marx PA, Roy CJ. (2012). Evaluation of inhaled cidofovir as postexposure prophylactic in an aerosol rabbitpox model. Antiviral Res., 93(1), 204-8.

Veazey RS, Marx PA. (2011). Symposium on Nonhuman Primate Models for AIDS. Introduction. J Med Primatol., 40(4), 205.

Schell JB, Rose NF, Bahl K, Diller K, Buonocore L, Hunter M, Marx PA, Gambhira R, Tang H, Montefiori DC, Johnson WE, Rose JK. (2011). Significant protection against high-dose simian immunodeficiency virus challenge conferred by a new prime-boost vaccine regimen. J Virol., 85(12), 5764-72.

Gautam R, Iyer A, Hunter M, Das A, Williams T, Dufour J, Apetrei C, Kousoulas KG, Marx PA. (2011). Vesicular stomatitis virus-simian retrovirus type 2 vaccine protects macaques from detectable infection and B-cell destruction. J Virol., 85(12), 5889-96.

Schwartz JA, Buonocore L, Suguitan A Jr, Hunter M, Marx PA, Subbarao K, Rose JK. (2011). Vesicular stomatitis virus-based H5N1 avian influenza vaccines induce potent cross-clade neutralizing antibodies in rhesus macaques. J Virol., 85(9), 4602-5.

Marx PA, Drucker EM, Schneider WH. (2011). The serial passage theory of HIV emergence. Clin Infect Dis., 52(3), 421

Ling B, Mohan M, Lackner AA, Green LC, Marx PA, Doyle LA, Veazey RS. (2010). The large intestine as a major reservoir for simian immunodeficiency virus in macaques with long-term, nonprogressing infection. J Infect Dis., 202(12), 1846-54.

Worobey M, Telfer P, Souquière S, Hunter M, Coleman CA, Metzger MJ, Reed P, Makuwa M, Hearn G, Honarvar S, Roques P, Apetrei C, Kazanji M, Marx PA. (2010). Island biogeography reveals the deep history of SIV. Science, 329(5998),1487.

Kirmaier A, Wu F, Newman RM, Hall LR, Morgan JS, O'Connor S, Marx PA, Meythaler M, Goldstein S, Buckler-White A, Kaur A, Hirsch VM, Johnson WE. (2010). TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species. PLoS Biol. 8(8), e100462.

Zao CL, Armstrong K, Tomanek L, Cooke A, Berger R, Estep JS, Marx PA, Trask JS, Smith DG, Yee JL, Lerche NW. (2010). The complete genome and genetic characteristics of SRV-4 isolated from cynomolgus monkeys (Macaca fascicularis). Virology, 405(2), 390-6.

Cenna J, Hunter M, Tan GS, Papaneri AB, Ribka EP, Schnell MJ, Marx PA, McGettigan JP. (2009). Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates. J Infect Dis., 200(8), 1251-60.

Hessell AJ, Poignard P, Hunter M, Hangartner L, Tehrani DM, Bleeker WK, Parren PW, Marx PA, Burton DR. (2009). Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat Med., 15(8), 951-4.

Gautam R, Gaufin T, Butler I, Gautam A, Barnes M, Mandell D, Pattison M, Tatum C, Macfarland J, Monjure C, Marx PA, Pandrea I, Apetrei C. (2009). SIVrcm, a unique CCR2-tropic virus, selectively depletes memory CD4+ T cells in pigtailed macaques through expanded coreceptor usage in vivo. J Virol. 83(16), 7894-908

Gautam R, Carter AC, Katz N, Butler IF, Barnes M, Hasegawa A, Ratterree M, Silvestri G, Marx PA, Hirsch VM, Pandrea I, Apetrei C.  (2007). In vitro characterization of primary SIVsmm isolates belonging to different lineages. Virology, 362(2), 257-70.

Apetrei C., Lerche N.W. ,Pandrea I.,Gormus B., Silvestri G., Kaur A., Robertson D.L., Hardcastle J.M., Lackner A.A., Marx PA. (2006). Kuru experiments triggered the emergence of pathogenic SIVmac. AIDS, 20(3), 317-321.

Apetrei, C., Becker J, Metzger MJ, Gautam R, Engle J, Wales AL, Eyong M, Enyong P, Foley BT, Drucker E, Marx PA. (2006). Potential for HIV transmission through unsafe injections. AIDS, 20, 1074-1076.

Apetrei C, Metzger MJ, Richardson D, Ling B, Telfer PT, Reed P, Robertson DL, Marx PA. (2005). Detection and Partial Characterization of Simian Immunodeficiency Virus SIVsm Starins From Bush Meat Samples from Rural Sierra Leone. Journal of Virology, 79, 2631-2636.

Traina-Dorge, Vicki L., Lorino R, Gormus B, Metzger MJ,Telfer P, Richardson D, Robertson DL, Marx PA, Apetrei C. (2005). Molecular epidemiology of simian T-cell lymphotropic virus type 1 in wild and captive sooty mangabeys. Journal of Virology, 79, 2541-2548.

Marx, PA
. (2005). Unsolved questions over the origin of HIV and AIDS. ASM News, 71, 15-20.


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Department of Tropical Medicine, 1440 Canal Street, Suite 2301, New Orleans, LA 70112, 504-988-3558