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Faculty

Yumei (3)

Yumei Feng, M.D., Ph.D.

Assistant Professor of Physiology

Email: yfeng1@tulane.edu
Phone: 504-988-8244
Fax: 504-988-2675
Department Personal Webpage
Lab website

Tulane University School of Medicine
Department of Physiology and Tulane Hypertension and Renal Center of Excellence
1430 Tulane Avenue, SL-39
New Orleans, LA 70112

Training

MD. Zhejiang University School of Medicine
Ph.D. Chongqing University of Medical Sciences
Postdoctoral training: Louisiana State University Health Sciences Center

Lab Research Interests

The research interest in our lab is the regulation of blood pressure and cardiovascular diseases in central nervous system. The renin-angiotensin system (RAS) has been shown to play an important role in blood pressure regulation and cardiovascular function. Our main focus is on the physiological and pathophysiological role of various new RAS components in disease models and their signaling pathways, and to improve the treatment of hypertension and other CV diseases. We use physiological genomics approaches, linking gene to function by using transgenic and knockout mice models. Using our expertise in continuous BP recordings (telemetry) and analysis of autonomic function combined to molecular biology, physiological, and pharmacological tools to investigate the role of these new components of the RAS on the regulation of BP and cardiovascular diseases.

Representative Publications

 

Wencheng Li, Hua Peng, Theresa Cao, Ryosuke Sato, Sarah J. McDaniels, Hiroyuki Kobori, L. Gabriel Navar, and Yumei Feng. Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension. Hypertension. 59: 1188-1194, 2012. PMID: 22526255

 

Yumei Feng, Huijing Xia, Yanhui Cai, Carmen M. Halabi, Becker LK, Santos RA, Speth RC, Curt D. Sigmund and Eric Lazartigues. Brain-selective over-expression of human Angiotensin Converting Enzyme 2 attenuates neurogenic hypertension. Circ Res. 106:373-382; 2010. (Selected for the Cover)  PMID: 19926873

 

Yumei Feng, Huijing Xia, Robson A. Santos, Robert Speth and Eric Lazartigues. ACE2: a new target for neurogenic hypertension. Exp Physiol. 95(5): 601-6, 2010. (Selected for the Cover) PMID: 19923158

 

Yumei Feng, Xinping Yue, Huijing Xia, Sharell Bindom, Peter Hickman, Catalin Filipeanu, Guangyu Wu and Eric Lazartigues. Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Res.102(6):729-36; 2008. PMID: 18258853

 

Huijing Xia, Sonia Suda, Sharell Bindom, Yumei Feng, Susan B. Gurley, Dale Seth, L. Gabriel Navar and Eric Lazartigues. ACE2-Mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One. 6(7): e22682. 2011. PMID: 21818366

 

Minolfa C. Prieto, Romer A. Gonzalez-Villalobos, Fady T. Botros, Victoria L. Martin, Javier Pagan, Ryosuke Sato, Lucieenne S. Lara, Yumei Feng, Fernanda Fernandez, Hiroyuki Kobori, Dulce E. Casarini, and L. Gabriel Navar. Reciprocal changes in renal ACE/Ang II and ACE2/Ang 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am J Physiol Renal Physiol. 300 (3): F749-55. 2011. PMID: 21209009

 

Chetan Hans, Yumei Feng, Amarjit Naura, Dana Troxclair, Amarjit S. Naura, Mourad Zerfaoui, Ju Jihang,  Alan D. Kaye,Eric Lazartigues, Yves A. DeClerck, and A. Hamid Boulares. Opposing roles of parp in mmp9 and timp2 expression and mast cell degranulation in dyslipidemic dilated cardiomypathy. Cardiovasc Pathol.20(2): e56-68, 2010. PMID: 20434371

 

Chetan Hans, Yumei Feng, Amarjit Naura, Mourad Zerfaoui, Bashir Rezk, Huijing Xia, Alan Kaye, Khalid Matrougui, Eric Lazartigues and Hamid Boulares. Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE-/- mice: effects on eNOS and oxidative stress.  PLoS One. 4(10): e7430; 2009. PMID: 19823587

 

Xiaoping Zhang, Guansong Wang, Denis J. Dupré, Yumei Feng, Mélanie Robitaille, Eric Lazartigues, Ying-Hong Feng, Terence E. Hébert, and Guangyu Wu. Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. J Pharmacol Exp Ther. 330(1):109-17; 2009. PMID: 19357319

 

Wei Xu, Lina Yi, Yumei Feng, Ling Chen and Jinsong Liu. Structure insight into the activation mechanism of human pancreatic prophospholipase A2. J Biol Chem. 284: 16659-16666; 2009. PMID: 19297324

 

Huijing Xia, Yumei Feng, Teresa D. Obr, Peter J. Hickman and Eric Lazartigues. AT1 receptor-mediated reduction of ACE2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension. 53(2):210-6; 2009. PMID: 19124678

 

Sungmi Park, Benjamin J. Bivona, Yumei Feng, Eric Lazartigues, and Lisa M. Harrison-Bernard. Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice. Am J Physiol Renal Physiol. 295:F1504-1511; 2008. PMID: 18753291

 

Eric Lazartigues, Yumei Feng and Julie Lavoie. The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases. Current Pharmaceutical Design.13: 1231-1245; 2007. PMID: 17504232

School of Science and Engineering, 201 Lindy Boggs Center, New Orleans, LA 70118 504-865-5764 sse@tulane.edu