shadow_tr

Faculty

faculty-prescott-deinigner

Prescott Deininger, Ph.D.

University of California, Davis, Physical Chemistry, 1978
Professor of Epidemiology


Email:
pdeinin@tulane.edu

Research Interests

Studies involve human genomics, gene regulation and instability of the human genome in cancer. Special emphasis on neural-specific RNA polymerase III-derived RNAs.

Representative Publications

M. El-Sawy, S.P. Kale, C. Dugan, T.Q. Nguyen, V. Belancio, H. Bruch, A.M. Roy-Engel, P.L Deininger. (2005) Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism. J. Mol. Biol. 354:246-57

Stephen L. Gasior, Melanie Palmisano, Prescott L. Deininger. (2005) Alu-linked hairpins efficiently mediate RNA interference with less toxicity than H1-expressed shRNAs. Anal Biochem. 349:41-8.

P. Deininger (2006) Alu elements. Genomic Disorders: The Genomic Basis of Disease (Lupski and Stankiewicz, eds) Human Press, pp 25-39.

S. Gasior, T. Wakeman, B. Xu, and P. Deininger. (2006) The Human LINE-1 Retrotransposon Creates DNA Double-Strand Breaks. J. Mol. Biol. 357:1383-93.

V. P. Belancio, D. Hedges, P. Deininger. (2006) LINE-1 RNA splicing and influences on mammalian gene expression. Nucleic Acids Res. 34:1512-21.

J. Xing, H. Wang, V.P. Belancio, R. Cordaux, P.L. Deininger and M.A. Batzer (2006) Emergence of new primate genes by retrotransposon-mediated sequence transduction. Proc. Natl. Acad. Sci. 103:17608-13.

V.P. Belancio, M. Whelton, and P. Deininger (2007) Requirements for polyadenylation at the 3’ end of LINE-1 elements. Gene 390, 98-107.

S. Gasior, G. Preston, D. Hedges, N. Gilbert, J. Moran and P. Deininger (2007) Characterization of pre-insertion loci of de novo L1 inserts. Gene 390, 190-198.

DJ Hedges and PL Deininger (2007) Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutat Res. 616, 46-59.

Belancio VP, Roy-Engel AM, Deininger P. (2008) The impact of multiple splice sites in human L1 elements. Gene 411:38-45.

Belancio VP, Hedges DJ, Deininger P. (2008) Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health. Genome Res 18:343-58.

SL Gasior and PL Deininger (2008) ERCC1/XPF limits L1 retrotransposition. DNA Repair 7:983-989 (2008) LINE-1 ORF1 protein enhances Alu SINE retrotransposition. Gene (in press)

School of Science and Engineering, 201 Lindy Boggs Center, New Orleans, LA 70118 504-865-5764 sse@tulane.edu