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Faculty

faculty-laura-schrader

Laura Schrader, Ph.D.

Professor of Cell and Molecular Biology


Email: schrader@tulane.edu

Dr. Schrader studies molecular mechanisms of synaptic plasticity and learning and memory. Techniques include: patch clamp electrophysiology in brain slices, behavioral paradigms, molecular biology and biochemistry. Her ultimate goal is to better understand how modulation of ion channels regulates neuronal excitability and synaptic plasticity in the context of learning and memory. Dr. Schrader teaches CELL 332/632 (Systems Neuroscience) and NSCI 604 (Trends in Neuroscience).

Research Interests

The main research interest in my lab involves investigation of regulation of neuronal excitability by ion channels. This research is relevant to normal plasticity processes, such as learning and memory and pathological processes such as epilepsy. Techniques include: patch clamp electrophysiology in brain slices, behavioral paradigms, molecular biology and biochemistry.

Representative Publications

Sol-Collado M, Lyons LC, Levenson JM, Khabour O, Pita-Almenar JD, Schrader L and Eskin A. (2007) In vivo regulation of an Aplysia Glutamate transporter, ApGT1, during long-term memory formation. J. Neurochemistry 100, 1315-28.

Ren Y, Barnwell FL, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, and Anderson AE. (2006) Regulation of surface localization of the small-conductance Ca2+-activated potassium channel, SK2 through direct phosphorylation by cylic AMP-dependent protein kinase. J. Biol. Chem. 281, 11769-11779.

Schrader LA, Birnbaum SG, Nadin B, Bui D, Anderson AE, Sweatt JD. (2006) ERK/MAPK Regulates the Kv4.2 Potassium Channel by Direct Phosphorylation of the Pore-forming Subunit. Am J Physiol. 290: C852-61.

Varga, AW, Yuan LL, Anderson AE, Schrader LA, Wu G-Y, Gatchel JR, Johnston D, Sweatt JD. (2004) CaMKII modulates Kv4.2 channel expression and upregulates dendritic A-type potassium currents. Journal of Neuroscience 24:3643-54.

Schrader, LA, Perrett, SP, Ye, L, and Friedlander, MJ (2004) Substrates for coincidence detection and calcium signaling for induction of synaptic potentiation in the neonatal visual cortex. J. Neurophys. 91:2747-64.

Shibata R., Mosono H., Campomanes CR, Anderson AE, Schrader LA, Dolivera LC, Carroll KI, Sweatt JD, Rhodes KJ, and Trimmer JS. (2003) Modulation of Kv4.2 Surface expression by Kv Channel Interacting Proteins. J. Biol Chem. 278: 36445 -36454 .

Schrader, LA, Anderson, AE, Mayne, A, Gutierrez, C, Pfaffinger, PJ, and Sweatt, JD (2002) PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. Journal of Neuroscience 22:10123-10133.

Schrader, LA and Tasker, JG. Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons. J. Neurophysiol. 77:527-536, 1997.

Boudaba, C. Schrader, LA, and Tasker, JG. Physiological evidence for local excitatory synaptic circuits in the rat hypothalamus. J. Neurophysiol. 77:3396-3400, 1997.

Schrader, LA and Tasker, JG Modulation of multiple potassium currents by metabotropic glutamate receptors in magnocellular neurons of the supraoptic nucleus. J. Neurophysiol. 78: 3428-3437, 1997.

Classes

Systems Neuroscience NSCI 332

School of Science and Engineering, 201 Lindy Boggs Center, New Orleans, LA 70118 504-865-5764 sse@tulane.edu