Tasker Faculty Photo_small

Jeffrey Tasker, Ph.D.

Catherine and Hunter Pierson Chair in Neuroscience
Professor of Cell and Molecular Biology

Website: The Tasker Lab

Dr. Tasker is researching the physiological and biochemical properties of brain cells that control pituitary hormone release. He teaches NSCI 3310/6310 (Cellular Neuroscience) and NSCI 7110 (Graduate Neuroscience).

Research Interests

University of Bordeaux, France, Neuroscience, 1986. Professor of Cell and Molecular Biology. Neurophysiology of neuroendocrine systems of the mammalian hypothalamus involved in stress, fluid and energy homeostasis and reproductive function using patch-clamp electrophysiology in brain slices, molecular biology and immunohistochemistry.

Representative Publications

Di, S. and Tasker, J.G.  Glial Control of Endocannabinoid Heterosynaptic Spillover in Hypothalamic Neuroendocrine Cells (submitted)

Nahar, J., Haam, J., Glatzer, N.R., Halmos, K.C., Muglia, L.J., Dohanich, G.P. and Tasker, J.G. Rapid Glucocorticoid Actions in Hypothalamic Neuroendocrine Cells are Dependent on the Glucocorticoid Receptor. Endocrinology (in revision)

Haam, J., Popescu, I.R., Morton, L.A., Halmos, K.C., Teruyama, R., Ueta, U. and Tasker, J.G.  (2012) GABA is excitatory in adult vasopressinergic neuroendocrine cells. Journal of Neuroscience 32:572-582.

Tasker J.G., Oliet SHR, Bains JS, Brown CH and Stern JE (2012) Glial regulation of neuronal function: From synapse to systems physiology. Journal of Neuroendocrinology 24: 566-576.

Levy, B.H. and Tasker, J.G. (2012) Synaptic regulation of the hypothalamic-pituitary-adrenal axis and its modulation by glucocorticoids and stress. Frontiers in Cellular Neuroscience 6:24.

Qiu J., Hindmarch C.C., Yao S.T., Tasker J.G., Murphy D. (2011) Transcriptomic Analysis of the Osmotic and Reproductive Remodeling of the Female Rat Supraoptic Nucleus. Endocrinology 152: 3483-3491.

Wardman, J.H., Berezniuk, I., Di, S., Tasker, J.G. and Fricker, L.D. (2011) ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS ONE 6(12): e28152.

Tasker JG and Herman JP (2011) Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-piutuitary-adrenal axis. Stress 14:398-406. (refereed invited review)

Popescu, I., Morton, L.A., Franco, A., Di, S., Ueta, Y. and Tasker, J.G. (2010) Synchronized bursts of miniature inhibitory postsynaptic currents. Journal of Physiology 588.6:939-951.

            - Selected as “Editor’s Choice” article in March issue of the Journal of Physiology; subject of Perspective article:  Behrends, J.C. (2010) An encounter of the third kind without the usual suspects: coherent activation of asynchronous transmitter release independent of presynaptic excitation. J Physiol            588.7:1031.

Evanson, N.K., Tasker, J.G., Hill, M.N., Hillard, C.J., and Herman, J.P. (2010) Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology 151:4811-4819.

Di, S., Maxson, M., Franco, A. and Tasker, J.G. (2009) Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent non-genomic signaling pathways. Journal of Neuroscience 29:393-401.

Flak, J.N., Ostrander, M.M., Mueller, N.M., Tasker, J.G. and Herman, J.P. (2009) Chronic stress-induced neurotransmitter plasticity within the hypothalamic paraventricular nucleus. Journal of Comparative Neurology 517:156-165.

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