James Zadina, Ph.D.

Professor of Medicine
Director of Neuroscience Laboratory, V. A. Medical Center


Dr. Zadina studies peptides, especially opioids; receptor binding, mechanisms of action, behavioral and developmental effects.

Research Interests

Tulane University, Physiological Psychology, 1978

Professor of Medicine, Tulane Univ. Sch. of Med.; Director, Neuroscience Laboratory, VA Medical Center. Peptides, especially opioids; receptor binding, mechanisms of action, behavioral and developmental effects.

Representative Publications

Aicher, S.A., Mitchell, J.L., Swanson, K.C., Zadina, J.E., 2003. Endomorphin-2 axon terminals contact mu-opioid receptor-containing dendrites in trigeminal dorsal horn. Brain Res. 977:190-8.

Wang, Q.P., Zadina , J.E., Guan, J.L., Kastin, A.J., Shioda, S., 2003. Electron microscopic examination of the endomorphin 2-like immunoreactive neurons in the rat hypothalamus. Brain Res. 969:126-34.

Greenwell, T.N., Zangen, A., Martin-Schild, S., Wise, R.A., Zadina, J.E., 2002. Endomorphin-1 and -2 immunoreactive cells in the hypothalamus are labeled by fluoro-gold injections to the ventral tegmental area. J. Comp. Neurol. 454:320-8.

Abbadie, C., Rossi, G.C., Orciuolo, A., Zadina, J.E., Pasternak, G.W., 2002. Anatomical and functional correlation of the endomorphins with mu opioid receptor splice variants. Eur. J. Neurosci. 16:1075-82.

Zadina, J.E., 2002. Isolation and distribution of endomorphins in the central nervous system. Jpn J Pharmacol. 89:203-8.

Zangen, A., Ikemoto, S., Zadina, J.E., Wise, R.A., 2002. Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens. J. Neurosci. 22:7225-33.

Wang, Q.P., Zadina, J.E., Guan, J.L., Kastin, A.J., 2002. Funahashi H, Shioda S. Endomorphin-2 immunoreactivity in the cervical dorsal horn of the rat spinal cord at the electron microscopic level. Neuroscience 113:593-605.

Kastin, A.J., Fasold, M.B., and Zadina, J.E., 2002. Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system. Drug Metab. Dispos. 30:231-4.

Martin-Schild, S.A., Gerall, A.A., Kastin, A.J. and Zadina, J.E. Differential distribution of endomorphin-1 and endomorphin-2-like immunoreactivities in the CNS of the rodent. J. Compar. Neurology 405:450-471, 1999.

Zadina, J.E., Hackler, L., Ge, L.-J., and Kastin, A.J. A potent and selective endogenous agonist for the µ-opiate receptor. Nature 386:499-502, 1997.

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