Allan V. Kalueff, PhD, PhD

RUDN State University, Moscow, Russia, Physiology, 2002
Tampere University, Tampere, Finland, Anatomy, 2005
Assistant Professor of Pharmacology

Phone: (504) 988-3354
Fax: (504) 988-5283

Department of Pharmacology
Tulane University Health Sciences Center
Rm. 3731
1430 Tulane Avenue, SL-83
New Orleans, LA 70112

Dr. Kalueff studies psychopharmacology of stress, anxiety and depression, Animal (experimental) models, Serotonin and serotonin syndrome, Epilepsy, Biological Psychiatry, Pharmacogenetics, Translational neuroscience non-synaptic mechanisms regulating neuronal excitability; regulation of neuronal/glial cell volume and ion concentrations; pathophysiology of stroke and epilepsy; changes with maturation.

Research Interests

Dr. Kalueff's lab studies Psychopharmacology of stress, anxiety and depression, Animal (experimental) models, Serotonin and serotonin syndrome, Epilepsy, Biological Psychiatry, Pharmacogenetics, and Translational neuroscience.

Our laboratory uses C. elegans, Zebrafish (Danio rerio) and Mice (Mus musculus) to explore the genetic, epigenetic, neurological and physiological foundations of anxiety, stress, depression and other brain disorders. Wild type and mutant (e.g., serotonin transporter, dopamine transporter) knockout C. elegans are utilized as a high throughput model to assess the physiological mechanisms affected by genetic variability and pharmacological treatment. We use zebrafish in various behavioral testing paradigms to explore various pharmacological treatments, such as anxiolytics, anxiogenics, and antidepressants. Similarly, wild type and mutant mice (e.g. serotonin transporter, dopamine transporter, BDNF knockouts) are examined in various behavioral assays to explore the impact of genetic, pharmacological and psychological factors on anxiety, stress and depression. A primary goal of this lab is to correlate these influences across levels of analysis and behavioral domains in order to develop a comprehensive understanding of these complex brain disorders.

Representative Publications

J.L. LaPorte, R.F. Ren-Patterson, D.L. Murphy, A.V. Kalueff (2008). Refining psychiatric genetics: from “mouse psychiatry” to understanding complex human disorders. Behav. Pharmacol., 19, 377-384.

A.V. Kalueff, R.F. Ren-Patterson, J.L. LaPorte, D.L. Murphy (2008). Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput phenotyping research. Behav. Brain Res., 188, 243-249.

A.V. Kalueff, J.L. LaPorte, D.L. Murphy, K.Sufka (2008). Hybridizing behavioral models: a possible solution to some problems in neurophenotyping research? Progress Neuro-Psychopharm. Biol. Psychiatry, 32, 1172-1178.

J. Zou, A. Minasyan, T. Keisalaa, Y. Zhang, J.-H. Wang, Y.-R. Lou, A.V. Kalueff, I. Pyykko, P. Tuohimaa (2008). Progressive hearing loss in mice with a mutated vitamin D receptor gene. Audiol. Neurotol., 13, 219-230.

A.V. Kalueff, J. LaPorte, D.L. Murphy (2008). Perspectives on genetic animal models of serotonin toxicity. Neurochem. Int., 52, 649-658.

A.V. Kalueff, A. Minasyan, T. Keisala, J.L. LaPorte, D.L. Murphy, P. Tuohimaa (2008). The regular and light-dark Suok "ropewalking" tests of anxiety and sensorimotor disintegration: utility for behavioral characterization in rodents. Nature Protocols, 3, 129-136.

A.V. Kalueff, K. Ishikawa, A. Griffith (2008). Anxiety and otovestibular disorders: linking behavioral phenotypes in men and mice. Behav. Brain Res., 186, 1-11.

A.V. Kalueff, J.W. Aldridge, J.L. LaPorte, D.L. Murphy, P.A. Tuohimaa. Analyzing grooming microstructure in neurobehavioral experiments. Nature Protocols, 2, 2538-2344.

School of Science and Engineering, 201 Lindy Boggs Center, New Orleans, LA 70118 504-865-5764