Ph.D., 2005, The Universtiy of Texas at Austin
5027 Percival Stern Building
Website: Professor Jayawickramarajah Group
Bio-Organic Chemistry, Nanobiotechnology, Molecular Recognition and Self-Assembly
Exquisitely controlled self-assembly in water is a key modality used by Nature to build highly functional biological systems. Research in the Jayawickramarajah group involves a highly interdisciplinary effort to develop bio-inspired functional molecules capable of undergoing specific molecular recognition events. A main thrust of our research is to study water compatible, self-assembling, synthetically functionalized oligomers that address contemporary problems. We are currently focused on the following two research areas.
- Development of Stimuli Responsive Protein-Binders Based on DNA-Small Molecule Chimeras. This project focuses on the development of DNA-small molecule chimeras that are programmed to bind and inhibit salient protein targets only upon non-covalent activation by specific endogenous or externally introduced trigger molecules. The development of general mechanisms for the non-covalent transformation of inactive protein inhibitors into activated compounds in the presence of specific endogenous (or externally added) stimuli is envisioned to contribute to prodrug development.
- Development of Well-Defined Porphyrin Arrays in Water: Towards Photonic Nanostructures. This project concerns the development of photonic nanowires composed of self-assembled multi-porphyrins in water. In these assemblies, the individual chromophores are non p-aggregated and are placed, via molecular recognition, at well-defined positions. The generation of self-assembled multi-porphyrin containing photonic nanostructures in water is envisioned to have potential applications as synthetic light harvesting antennae, catalyst arrays, and chemo-responsive sensing materials.
As a result of our prepare-and-analyze philosophy, students in the laboratory will be versed in synthetic organic chemistry and chemical biology, as well as being proficient in a whole host of spectroscopic, microscopic, and analytical techniques.