PhD, 1976, Harvard University
The research interests of my group are primarily in the area of synthetic organic chemistry and the synthesis of biologically active natural products. These interests are interconnected, since the synthesis of complex natural products frequently demands that new synthetic procedures be explored and developed. One projects include the preparations of naturally occurring oligio sacharides as well as various environmental studies.
“An efficient method for the preparation of glycosides with a free C-2 hydroxyl group from thioglycosides.” Hai Yu, Harry E. Ensley, Tetrahedron Lett., 44(52), 9363-9366 (2003).
“Pharmacokinetics of fungal (1-3)-β-D-glucans following intravenous administration in rats.” Rice, Peter J.; Lockhart, Brent E.; Barker, Luke A.; Adams, Elizabeth L.; Ensley, Harry E.; Williams, David, L; Internat. Immunopharm., 4(9), 1209-1215 (2004).
“Novel monoclonal antibodies with specificity for chelated uranium(VI): Isolation and binding properties.” R.C. Blake II, A.R. Pavlov, M. Khosraviani, H.E. Ensley, G.E. Kiefer, H. Yu, X. Li, and D.A. Blake, Bioconjugate Chemistry 15:1125-1136 (2004).
“4-Acetoxy-2,2-dimethylbutanoate:A useful carbohydrate protecting group for the selective formation of _-(1÷3)-D-glucans.” , Hai Yu, David L. Williams and Harry E. Ensley, Tetrahedron Lett., 46 (19) 3417-3421(2005).
“Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.” Rice, Peter J.: Adams, Elizabeth L.; Ozment-Skelton, Tammy; Gonzalez, Andres J.; Goldman, Matthew P.; Lockart, Brent E.; Barker, Luke A.; Breuel, Kevin F.; DePonti, Warren K.; Kalbfleisch, John H.; Ensley, Harry E.; Brown Gordon D.; Gordon, Siamon; Williams, David L.; Journal of Pharmacology and Experimental Therapeutics 314(3), 1079-1086 (2005).
“Introduction to the chemistry and immunobiology of b-glucans” David L. Williams, Douglas W. Lowman and Harry E. Ensley in Toxicology of 1®3-Beta-Glucans , pp 1-34 S-H. Young and V. Castranova, Eds. CRC Press (2005).
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