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2014-03-11 - Christel Hohenegger


Time/Place:

Tuesday, March 11, 2014
3:00pm
316 Stanley Thomas Hall
Tulane University (Uptown)

Refreshments will be served


Speaker:

Christel Hohenegger, University of Utah


Title:

Fluid coupling in continuum modeling of microtubular gliding assays


Abstract:

Active networks are suspensions of actuated filaments obtained by mixing cytoskeletal filaments and small motor protein complexes. The network activity is achieved by the motion of the motor proteins along the filaments. Here, we focus on gliding assays, where the molecular motors are anchored to a bottom plate and filaments are observed to glide in a quasi two-dimensional plane. In contrast to other studies, we are not interested in the detailed motion of each individual filament but only in the resulting coarse grained properties. We present a new continuum macroscopic model of gliding assays including the evolution of rigid filaments density, bound and free motors densities and fluid velocity. Our model combines continuum theories of polymeric liquids with the force spreading approach of the immersed boundary method. We focus on cumulative hydrodynamic effects and our numerical simulations show the emergence of ordered subregions (swirls, high density traveling bands, moving clusters) of filaments and motors arising from the hydrodynamic coupling of the fluid and the suspended microstructures, similar to those observed experimentally.

This is joint work with Tamar Shinar and Steve Cook (UC Riverside).

Center for Computational Science, Stanley Thomas Hall 402, New Orleans, LA 70118 ccs@tulane.edu