300 Lindy Boggs Building
Department of Chemical and Biomolecular Engineering
New Orleans, LA 70118-5674
The Robinson laboratory is interested in understanding the fundamental interactions between molecules, both in isolation and in the complex environment of the cell. We use our growing understanding to design proteins with more robust or novel properties and to engineer cellular systems for improved production or drug screening applications. To this end, we are investigating the determinants of protein folding and misfolding, on both atomic and molecular levels. We have developed several novel approaches to inhibit protein misfolding and aggregation. Additionally, we are designing cellular systems for optimal expression of membrane proteins and antibodies.
A major goal of this research is to establish a set of cellular systems that could express any protein of interest. Recently, we have begun studies to understand the cellular interactions that lead to hyperphosphorylation and aggregation of tau protein, which is relevant to Alzheimer’s disease, and several other neurodegenerative diseases including corticobasal degeneration.
Our approach uses techniques in molecular biology, genetic engineering, and biophysical chemistry to identify and study macromolecules at both an atomic and cellular level. Mechanistic modeling guides us in experimental design and analysis. We use both prokaryotic (bacterial) systems as well as eukaryotic systems, such as yeast or mammalian cells. The research in the laboratory has focus areas in protein stability, expression, and aggregation for biotechnology and biomedical applications.
B.S., Johns Hopkins University, 1988
M.S., Johns Hopkins University, 1989
Ph.D., University of Illinois at Urbana-Champaign, 1994
Anne Skaja Robinson joined Tulane University in January 2012 as the Chair of Chemical and Biomolecular Engineering. Prior to Tulane, Dr. Robinson was a Full Professor and Associate Chair at the University of Delaware, where she started her academic career. She earned her Bachelor’s and Master’s degrees in Chemical Engineering from the Johns Hopkins University. She earned her PhD in Chemical Engineering from the University of Illinois at Urbana-Champaign, and was an NIH postdoctoral fellow in the Department of Biology at MIT before joining the faculty at UD. Her honors include a DuPont Young Professor Award, and a National Science Foundation Presidential Early Career Award for Science and Engineering (PECASE) Award, and she is a fellow of the American Institute for Medical and Biological Engineering. She has several patents and over 70 publications in the field of biochemical engineering.
300 Lindy Boggs Center, Tulane University, New Orleans, LA 70118, T: 504-865-5772, F: 504-865-6744 email@example.com