September 14, 2012
Dr. Sergey Shevkoplyas, The Ken and Ruth Arnold Early Career Professor in Biomedical Engineering, is the recipient of a highly competitive NIH Director's Transformative Research Award (also known as TR01). Only 20 awards were given this year, to pursue visionary science that exhibit the potential to transform scientific fields and speed the translation of research into improved health, under the High Risk-High Reward program supported by the National Institutes of Health Common Fund.
The NIH Director's Transformative Research awards encourage creative thinkers to pursue exciting and innovative ideas about biomedical and behavioral research. The program, established in 2009, promotes cross-cutting, interdisciplinary approaches and is open to individuals and teams of investigators who propose research that has the potential to create or overturn fundamental paradigms. "The Common Fund High Risk-High Reward program provides opportunities for innovative investigators in any area of health research to take risks when the potential impact in biomedical and behavioral science is high," said NIH Director Francis S. Collins, M.D., Ph.D.
Dr. Shevkoplyas’ TR01 proposal entitled “Eliminating Mediators of Toxicity from Stored Blood” was judged to be high-risk and high-reward, and highly innovative. If successful, this project will have a potentially game-changing, transformative impact on the safety and efficacy of transfusions administered throughout the practice of medicine.
With nearly 15 million units of red blood cells (RBCs) transfused to about 5 million patients in the U.S. every year, RBC transfusion is one of the most commonly prescribed therapies for hospital inpatients. Most transfusions involve RBCs that had been stored in an anticoagulant-preservative solution at 1-6°C for up to 6 weeks. During hypothermic storage, a significant fraction of stored RBCs becomes irreparably damaged and the storage medium accumulates known mediators of toxicity as byproducts of RBC metabolism and degradation. Infusion of these toxic mediators and the irreparably damaged cells into the recipient during transfusion reduces the therapeutic efficacy of transfusion and contributes to multiple adverse outcomes in about 1-2% of U.S. citizens every year. The goal of this project is to develop technology for high-throughput removal of irreparably damaged cells and toxic mediators accumulating in the storage medium from RBC units during the transfusion process.
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