Assistant Professor of Biomedical Engineering
Phone: (504) 865-5851
536 Lindy Boggs Building
Department of Biomedical Engineering
New Orleans, LA 70118
Research in our laboratory focuses on the application and translation of quantitative spectroscopy and imaging tools for the improvement of cancer management in the clinical setting. We develop translatable optical methods to directly address gaps in clinical care, and carry those through to clinical validation in humans alongside our physician collaborators. A major theme in this work is the use of spectroscopy and imaging devices to improve patient outcomes in surgical tumor removal in a number of organs. We also develop tools and strategies using optics to answer interesting biological questions in cell and animal models (for example, imaging of tumor hypoxia and metabolism).
Fall: BMEN 6931 - Introduction to Biomedical Optics
Millon SR, Ostrander JH, Brown JQ, Rajeha A, Ramanujam N, “Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines,” Breast Cancer Research and Treatment, 126:55-62, 2011.
Kennedy SA, Geradts J, Bydlon TM, Brown JQ, Gallagher J, Junker M, Barry WT, Ramanujam N, Wilke LG, “Optical breast cancer margin assessment: An observational study on the effects of tissue heterogeneity on optical contrast,” Breast Cancer Research, 12:R91, 2010.
Brown JQ, Bydlon TM, Richards LM, Yu B, Kennedy SA, Wilke LG, Geradts J, Junker M, Gallagher J, Ramanujam N, “Optical assessment of tumor resection margins in the breast,” Invited paper, IEEE Journal of Selected Topics on Quantum Electronics, 16:530-544. 2010.
Ostrander JH, McMahon CM, Lem S, Millon S, Brown JQ, Seewaldt V, Ramanujam N., “Optical redoxratio differentiates breast cancer cell lines based on receptor status,” Cancer Research, 70:4759-66, 2010.
Bydlon TM, Kennedy SA, Richards LM, Brown JQ, Yu B, JunkerMK, Gallagher J, Geradts J, Wilke LG, Ramanujam N., “Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins,” Optics Express, 18:8058-8076, 2010.
Millon SR, Ostrander JH, Yazdanfar S, Brown JQ, Bender JE, Rajeha A, Ramanujam N., “Preferential accumulation of ALA-induced PpIX in breast cancer: A comprehensive study on six breast cell lines,” Journal of Biomedical Optics, Vol. 15, 018002 (Feb. 18, 2010).
Wilke LG, Brown JQ, Bydlon TM, Kennedy SA, Richards LM, Junker M, Gallagher J, Barry WT, Geradts J, Ramanujam N, “Rapid non-invasive optical imaging of tissue composition in breast tumor margins.” American Journal of Surgery, 198:566-574, 2009.
Brown JQ, Vishwanath K, Palmer GM, Ramanujam N., “Advances in quantitative UV-visible spectroscopy for clinical and pre-clinical application in cancer,” Current Opinion in Biotechnology, 20:119-131, 2009.
Brown JQ, Wilke LG, Geradts J, Kennedy S, Palmer GM, Ramanujam N, “Quantitative optical spectroscopy: A robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo,” Cancer Research, 69:2919-2926, 2009.
Bender JE, Vishwanath K, Moore LK, Brown JQ, Chang V, Palmer GM, Ramanujam, N. “A Robust Monte Carlo Model for the Extraction of Biological Absorption and Scattering in Vivo,” IEEE Trans BME, 56:960- 968, 2009.
Brown JQ, Srivastava R, Zhu H, McShane MJ, “Enzymatic Fluorescent Microsphere Glucose Sensors: Evaluation of Response Under Dynamic Conditions,” Diabetes Technology and Therapeutics, 8:288-295. 2006.
Brown JQ, McShane MJ, “Modeling of Spherical Enzymatic Fluorescent Glucose Microsensor Systems: Design of Smart Tattoos,” Biosensors and Bioelectronics, 21:1760-1769. 2006.
Lindy Boggs Center Suite 500, Tulane University, New Orleans, LA 70118 504-865-5897 email@example.com