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Hypertension & Renal Center of Excellence
1430 Tulane Avenue
New Orleans, LA 70112
Phone: (504) 988-3703
Fax: (504) 988-2675

 

COBRE
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THRCE awarded $5.4 million grant to maintain the COBRE


In 2012, the Tulane Hypertension and Renal Center of Excellence was awarded a 5 year, $5.4 million grant in order to maintain the Center of Biomedical Research Excellence (COBRE) Phase III Translational Research in Hypertension and Renal Biology. The competitive award is administered by the National Institute of General Medical Sciences (NIGMS). The principal investigator (PI) of the award is Dr. L. Gabriel Navar who, along with Dr. L. Lee Hamm, will continue to direct the COBRE program.

Tulane University Hypertension and Renal Center of Excellence (THRCE) was first established in 2002 by the NIH as one of its Centers of Biomedical Research Excellence (COBRE Phase I) with a 5 year, $10.8 million grant.  Then in 2007, the center was successful in competing for the 5 year COBRE Phase II grant that awarded over $11 million to continue its research in the field of high blood pressure and its effect on the kidneys as well as the role of kidneys in the development of high blood pressure.  

COBRE Phases I and II provided support for 16 junior faculty members, of which 7 received NIH research funding, 19 postdoctoral fellows, 12 graduate students, and 29 medical students. In addition, the research infrastructure was markedly enhanced by the Molecular, Imaging, and Analytical Core with state-of-the-art facilities, and Transgenic Animal Core serving members of the Hypertension and Renal Center. The long-term goals of the COBRE Phase III Award are to provide an enriched environment to all investigators so that they can maintain nationally competitive status as well as to augment and strengthen the biomedical research capacity and infrastructure for Tulane investigators in hypertension, renal and cardiovascular disease. These goals will be achieved by:

  1. Providing support for maintaining the COBRE research CORES developed during Phases I and II that are essential for continuing the center’s basic, clinical, and translational research. These Cores include the Administrative Core, Mouse Phenotyping Core, Molecular & Analytical Core, Transgenic & Animal Core and the Clinical and Translational Core
  2. Enhancing the research infrastructure at Tulane Health Sciences Center in the multidisciplinary area of hypertension, renal and vascular biology thus maintaining and increasing national competitiveness for NIH and other federal grants by our faculty investigators.
  3. Encouraging and facilitating collaborative interactions between basic science investigators and clinical translational scientists in hypertension and related areas at Tulane Health Sciences Center.
  4. Sustaining a collaborative multidisciplinary research environment by providing support for research pilot projects and mentoring and training components. 

The overall outcome of COBRE Phase III will contribute to an increased understanding of the multiple interactions leading to the pathophysiological derangements that lead to hypertension and associated kidney and cardiovascular diseases. COBRE Phase III, like phases I & II, will continue to increase the number of competitive scientists in a disease specific area of extremely high biomedical relevance in this region. 

Each year, will provide three pilot projects $50,000 research support to selected scientists from the Medical School, the School of Public Health and Tropical Medicine, and the School of Science and Engineering. The pilot project awards will provide one year research opportunities for novel, innovative, highly competitive meritorious projects with high likelihood for garnering extramural research support. Projects that address important, novel and significant issues related to the broad area encompassed by hypertension, renal and cardiovascular research will be considered. Applications will be subjected to a rigorous internal and external review process to ensure that funds are provided only to highly meritorious pilot projects that are likely to lead to extramural research support and will stimulate multidisciplinary collaborative interactions. 2013-2014 Pilot Project award recipients are Kenneth D. Mitchell, Ph.D., Ryosuke Sato, Ph.D., and Ihor V. Yosypiv, M.D. The three pilot projects are as follows:

  • Pilot Project 1:
    PDGF Receptor Blockade Reverses the Renal Functional and Morphological Changes that occur in AngiotensinII-Dependant Hypertension.
    ~ PI: Kenneth D. Mitchell, Ph.D.
  • Pilot Project 2:
    Angiotensinogen Expression and Regulation in Renal Proximal Tubules during the Development of Angiotensin-II-Dependent Hypertension
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    ~ PI: Ryosuke Sato, Ph.D.
  • Pilot Project 3:
    Prorenin Receptor in Collecting Duct Development.
    ~ PI: Ihor V. Yosypiv, M.D.
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Tulane University, New Orleans, LA 70118 504-865-5000 website@tulane.edu