My research concerns the pathobiology of stress-associated psychiatric diseases, like anxiety and depression. More specifically, the outcome of gene by environment interaction are studied by assessing epigenetic, endocrine, behavioral, physiological and neuroanatomical aspects of the stress 9aml)adaptation response. Special focus is on the interplay of stress, mitochondrial (dys)function and gender. My laboratory uses various animal models, such as conditional transgenic and adenoviral approaches to specifically control gene expression in a temporal and site-specific manner, as well as human post-mortem brain samples.
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