Vice Chair for Research
Interleukin-17 in Prostate Cancer. A major focus of our research program is to understand the role of inflammation in cancer initiation, promotion, and progression. Our target molecule in inflammation is interleukin-17 (IL-17). IL-17 is a key cytokine in many inflammatory and autoimmune diseases. We are using in-vitro and in-vivo (transgenic and knockout mice) approaches to determine the role of IL-17 signaling in initiation, promotion, and progression of prostate cancer. The long-term goals of these studies are to identify the molecular mechanisms of IL-17 signaling pathways, to develop new methods targeting IL-17 signaling, and to apply these methods in prevention and treatment of prostate cancer.
Doublecortin in Articular Joint Development. This research program is to understand the role of doublecortin (DCX) in development of articular joint. DCX was originally identified in migrating and differentiating neurons by other investigators. We were the first group to identify DCX in articular chondrocytes. Our current studies are to identify the molecular mechanisms of DCX’s function and to determine the role of DCX in differentiation of stem cells into articular chondrocytes. The long-term goals are to design new approaches in tissue engineering and regeneration of articular joint by manipulating DCX expression.
Other Academic Affiliations:
Adjunct Associate Professor in Department of Orthopaedic Surgery
Program Member of Tulane Cancer Center, Louisiana Cancer Research Consortium
Faculty Member of Tulane Center for Aging
Faculty Member of Tulane Center for Stem Cell Research and Regenerative Medicine
Zongbing You, Ying Dong, Xiangtian Kong, Laurel A. Beckett, Regina Gandour-Edwards, and Jonathan Melamed. Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival. BMC Medical Genomics 2008, 1:6.
Dongxia Ge, Zongbing You. Expression of interleukin-17RC protein in normal human tissues.International Archives of Medicine 2008, 1:19.
Junliang Ma, Lunxu Liu, Guowei Che, Nanbin Yu, Fuqiang Dai, and Zongbing You. The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time. BMC Cancer 10:112.
Fuqiang Dai, Lunxu Liu, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma and Zongbing You. The number and microlocalization of tumor-associated immune cells are associated with patient's survival time in non-small cell lung cancer. BMC Cancer 10 (2010) 220.
Q. Zhang, A.D. Cigan, L. Marrero, C. Lopreore, S. Liu, D. Ge, F.H. Savoie, and Z. You, Expression of doublecortin reveals articular chondrocyte lineage in mouse embryonic limbs. Genesis 49 (2011) 75-82. PMID: 21162077.
T. Lai, K. Wang, Q. Hou, J. Zhang, J. Yuan, L. Yuan, Z. You*, and M. Xi*, Interleukin 17 Induces Up-Regulation of Chemokine and Cytokine Expression Via Activation of the Nuclear Factor kappaB and Extracellular Signal-Regulated Kinase 1/2 Pathways in Gynecologic Cancer Cell Lines. Int J Gynecol Cancer (2011). 21: 1533-9.
Dongxia Ge, Allen C. Gao, Qiuyang Zhang, Sen Liu, Yun Xue, and Zongbing You. LNCaP Prostate Cancer Cells with Autocrine Interleukin-6 Expression Are Resistant to IL-6-induced Neuroendocrine Differentiation due to Increased Expression of Suppressors of Cytokine Signaling. The Prostate, 2012 Sep 1;72(12):1306-16.
Qiuyang Zhang, Sen Liu, Dongxia Ge, Qingsong Zhang, Yun Xue, Zhenggang Xiong, Asim B. Abdel−Mageed, Leann Myers, Steven M. Hill, Brian G. Rowan, Oliver Sartor, Jonathan Melamed, Zhenbang Chen, and Zongbing You. Interleulin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models. Cancer Research, 72 (10):2589-99, 2012– featured on the cover of the May 15, 2012 issue of Cancer Res.
Zongbing You, Dongxia Ge, Sen Liu, Qiuyang Zhang, Alexander D. Borowsky, and Jonathan Melamed. Interleukin-17 Induces Expression of Chemokines and Cytokines in Prostatic Epithelial Cells but Does Not Stimulate Cell Growth In Vitro. International Journal of Medical and Biological Frontiers. 2012, 18 (8): 629-644.
Lunxu Liu, Dongxia Ge, Lin Ma, Jiandong Mei, Sen Liu, Qiuyang Zhang, Fuqiang Ren, Hu Liao, Qiang Pu, Tao Wang, and Zongbing You. Interleulin-17 and Prostaglandin E2 Are Involved in Formation of an M2 Macrophage-dominant Microenvironment in Lung Cancer. J Thoracic Oncology, 2012 Jul; 7(7):1091-1100.
Qingli Li, Mark J. Lambrechts, Qiuyang Zhang, Sen Liu, Dongxia Ge, Rutie Yin, Mingrong Xi, Zongbing You.Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis. Drug Design, Development and Therapy, July 24, 2013, 7: 635-643.
Tulane University School of Medicine, Dept. of SCB, New Orleans, LA 70112 504-988-5255 firstname.lastname@example.org