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Structural & Cellular Biology
Tulane University School of Medicine
Box SL49, Room 3004
1430 Tulane Avenue
New Orleans, Louisiana 70112
Telephone: (504) 988-5255
Fax: (504) 988-1687
Guoyong Wang, M.D., Ph.D.

wangAssistant Professor

gwang@tulane.edu

Research Interests:

Retinal ganglion cells are the only output neurons of retina. All information about the visual world is conveyed from the eyes to the visual centers of the brain by these neurons. How are these neurons functioning is the essential question in visual system. My research is focus on functional and structural organization of retinal ganglion cells in developing and mature retina.

Selected Publications:

Huang W, Wu G, Wang GY. Cell type-specific and light-dependent expression of Rab1 and Rab6 GTPases in mammalian retinas. Vis Neurosci. 2009 Nov;26(5-6):443-52. Epub 2009 Dec 11.

Nemargut JP, Wang GY. Inhibition of nitric oxide synthase desensitizes retinal ganglion cells to light by diminishing their excitatory synaptic currents under light adaptation. Vision Res. 2009 Dec;49(24):2936-47. Epub 2009 Sep 20.

Bai X, Zhu J, Yang J, Savoie BT, Wang GY. Mechanisms that limit the light stimulus frequency following through the DL-2-amino-4-phosphonobutyric acid sensitive and insensitive rod Off-pathways. Neuroscience. 2009 Aug 4;162(1):184-94. Epub 2009 May 3.

Nemargut JP, Zhu J, Savoie BT, Wang GY. Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina. Vision Res. 2009 Feb;49(3):388-97. Epub 2008 Dec 30.

Wang GY, van der List DA, Nemargut JP, Coombs JL, Chalupa LM. The sensitivity of light-evoked responses of retinal ganglion cells is decreased in nitric oxide synthase gene knockout mice. J Vis. 2007 Nov 30;7(14):7.1-13.

Wang GY. Unique functional properties of the APB sensitive and insensitive rod pathways signaling light decrements in mouse retinal ganglion cells. Vis Neurosci. 2006 Jan-Feb;23(1):127-35.

Wang, GY, Liets, LC., Chalupa, LM. (2003) Nitric oxide differentially modulates On and Off responses of retinal ganglion cells. Journal of Neurophysiology, 90: 1304-1313.

Huberman, A., Wang, GY, Liets, LC., Collins, OA., Chapman, B., Chalupa, LM. (2003) Eye-specific retinogeniculate segregation independent of normal neuronal activity. Science 300: 994-998.

Liets, LC., Olshausen, B.A., Wang, GY, Chalupa, L.M. (2003) Spontaneous activity of morphologically identified ganglion cells in the developing ferret retina. Journal of Neuroscience, 23(19): 7343-7350.

Wang, GY, Liets, LC., Chalupa, L.M. (2001) Unique functional properties of On and Off pathways in the developing mammalian retina. Journal of Neuroscience, 21(12): 4310-4317.

Wang, GY, Olshausen, B.A., Chalupa, L.M. (1999) Differential effects of apamin- and charybdotoxin-sensitive K+ conductances on spontaneous discharge patterns of developing retinal ganglion cells. Journal of Neuroscience, 19(7):2609-18.

Robinson, D.W. and Wang, GY (1998) Development of intrinsic membrane properties in mammalian retinal ganglion cells. Seminars in Cell and Developmental Biology, 9(3):301-10.

Wang, GY, Robinson, D.W. and Chalupa, L.M. (1998) Calcium-activated potassium conductances in retinal ganglion cells of the ferret. Journal of Neurophysiology, 9(1):151-8.

Wang, GY, Ratto, G., Bisti, S., and Chalupa, L.M. (1997) Functional development of intrinsic properties in ganglion cells of the mammalian retina. Journal of Neurophysiology, 78(6):2895-903.

Tulane University School of Medicine, Dept. of SCB, New Orleans, LA 70112 504-988-5255 tfrasch@tulane.edu