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Prieto


Minolfa C. Prieto, MD, PhD
Assistant Professor
Phone: (504) 988-2445
Room #: 4061

Email: mprieto@tulane.edu

MD: Universidad del Zulia, Venezuela, 1985
PhD: Tulane University, 2004


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Research Interests:

Research in my lab is focused on the intrarenal regulation of the RAS in hypertension. My training in molecular genetics and renal physiology with emphasis on experimental hypertension has allowed focusing my efforts on investigating the functional role and the regulation of intrarenal RAS genes in the pathophysiology of hypertension and related renal morphological changes. In particular, investigating the role of prorenin and renin from collecting duct cells origin and their interaction with the prorenin receptor in the pathogenesis of high blood pressure. Other research includes the importance of elucidating the fundamental basis of the sex dependent differences in the intrarenal RAS that likely explain sex disparities in hypertension. I have pioneered the studies on the activation of collecting duct renin and prorenin during Ang II-dependent hypertension including cell-type localization and regulation of synthesis and secretion in rodent models.

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Prieto - lab

Laboratory Members:


  • Alexis A. Gonzalez – Postdoctoral Fellow
  • Marta Kuczeriszka – Postdoctoral Fellow
  • Liu Liu – Graduate Student
  • Camille Bourgeois – Lab Research Technician


  Prieto - activity                    Prieto - tech


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Representative Publications:

  1. Crowley SD, Vasievich MP, Ruiz P, Gould SK, Parsons KK, Pazmino AK, Facemire C, Chen BJ, Kim H-S, Tran TT, Pisetsky DS, Barisoni L, Prieto-Carrasquero MC, Jeansson M, Foster MH, Coffman TM. GLORMERULAR TYPE 1 ANGIOTENSIN RECEPTORS AUGMENT KIDNEY INJURY AND INFLAMMATION IN MURINE AUTOIMMUNE NEPHRITIS. J Clin Invest. Apr; 119(4):943-953, 2009.
  2. Romer Gonzalez-Villalobos, Ryousuke Satou, Naro Ohashi, Laura Semprun-Prieto, Akemi Katsurada, Catherine Kim, G. Upchurch, Minolfa Prieto, Hiroyuki Kobori, L. Navar. INTRARENAL MOUSE RENIN-ANGIOTENSIN SYSTEM DURING ANG II-INDUCED HYPERTENSION AND ACE INHIBITION. Am J Physiol Renal Physiol; 298 F150-F157, 2010.
  3. Dustyn E. Williams, Minolfa C. Prieto, John J. Mullins, L. Gabriel Navar, and Kenneth D. Mitchell. AT1 RECEPTOR BLOCKADE PREVENTS THE INCREASE IN BLOOD PRESSURE AND THE AUGMENTATION OF INTRARENAL ANG II LEVELS IN HYPERTENSIVE Cyp1a1-Ren2 TRANSGENIC RATS FED A HIGH SALT DIET. Am J Med Sci; 339(4):356-361, 2010.
  4. L. Gabriel Navar, Minolfa C. Prieto, Ryosuke Sato, Hiroyuki Kobori. INTRARENAL ANGIOTENSIN II AND ITS CONTRIBUTION TO THE GENESIS OF CHRONIC HYPERTENSION. Current Opinion in Pharmacology, 11:180-186, 2011.
  5. L. Gabriel Navar, Hiroyuki Kobori, Minolfa C. Prieto, and Romer A. Gonzalez-Villalobos. INTRATUBULAR RENIN-ANGIOTENSIN SYSTEM IN HYPERTENSION. Hypertension;57:355-362, 2011.
  6. Minolfa C. Prieto, Fady T. Botros, Victoria L. Martin, Hiroyuki Kobori, Javier Pagan, Ryosuke Sato, Romer Gonzalez-Villalobos, Dulce E. Casarini and L Gabriel Navar. RECIPROCAL CHANGES IN ACE/ANG II AND ACE2/ANG 1-7 ARE ASSOCIATED WITH ENHANCED COLLECTING DUCT RENIN IN THE RENAL MEDULLA OF GOLDBLATT HYPERTENSIVE RATS. (Am J Physiol Renal Physiol 300:F749-F755, 2011.
  7. Minolfa C. Prieto, Dustyn E. Williams, Liu Liu, Kimberly L Kavanagh, John J Mullins, and Kenneth Mitchell. ENHANCEMENT OF RENIN AND PRORENIN RECEPTOR IN DISTAL NEPHRON SEGMENTS OF CY1A1-Ren2 TRANSGENIC RATS MAY CONTRIBUTE TO DEVELOPMENT AND PROGRESSION OF MALIGNANT HYPERTENSION. Am J Physiol Renal Physiol; 300:F581-F588, 2011.
  8. Navar LG, Kobori H, Prieto MC, Gonzalez-Villalobos RA. Intratubular renin-angiotensin system in hypertension. Hypertension. 2011 Mar;57(3):355-62.
  9. Alexis A. Gonzalez, Liu Liu, Lucienne S. Lara, Dale M. Seth, L Gabriel Navar, and Minolfa C. Prieto. ANGIOTENSIN II STIMULATES RENIN IN THE COLLECTING DUCT CELLS VIA PROTEIN KINASE C AND INDEPENDENT OF ENAC AND MINERALOCORTICOID RECEPTOR ACTIVITY. Hypertension; 57:594-599, 2011.
  10. Alexis A. Gonzalez, Lucienne S. Lara, Dale M. Seth and Minolfa C. Prieto. THE SOLUBLE FORM OF THE PRORENIN RECEPTOR [S(PRR)] IS AUGMENTED IN THE COLLECTING DUCTS AND IN THE URINE OF ANGIOTENSIN II (ANG II)-DEPENDENT HYPERTENSIVE RATS. Hypertension, 57:859-864, 2011.
  11. Navar LG, Prieto MC, Satou R, Kobori H. INTRARENAL ANGIOTENSIN II AND ITS CONTRIBUTION TO THE GENESIS OF CHRONIC HYPERTENSION. Curr Opin Pharmacol. 2011 Apr;11(2):180-6.
  12. Liu Liu, Alexis A. Gonzalez, Michael McCormack, Dale M. Seth, Hiroyuki Kobori, L. Gabriel Navar and Minolfa C. Prieto. INCREASED RENIN EXCRETION IS ASSOCIATED WITH AUGMENTED URINARY ANGIOTENSIN (ANG) II LEVELS IN CHRONIC ANG II-INFUSED HYPERTENSIVE RATS. Am J Physiol Renal Physiol; 301(6):F-1195-F11201, 2011.
  13. Lucienne S. Lara, Michael McCormack, Vicky F. Rands, Laura Semprun-Prieto, Sylvia Shenouda, Dewan Syed Abdul Majid, Hiroyuki Kobori, L Gabriel Navar, and Minolfa C. Prieto. AT1 RECEPTOR MEDIATED AUGMENTATION OF ANGIOTENSINOGEN, OXIDATIVE STRESS AND INFLAMMATION IN ANGIOTENSIN II-SALT HYPERTENSION. Am J Physiol Renal Physiol; 302:F-85-F94, 2012.
  14. Roy A, Khan AH, Islam MT, Minolfa C. Prieto, and Dewan Majid. INTERDEPENDENCY OF CYSTATHIONE δ-LYASE AND CYSTATHIONE β-SYNTHASE ENZYMES IN HYDROGEN SULFIDE INDUCED BLOOD PRESSURE REGULATION IN RATS. J Hypertension; 25(1):74-81, 2012.
  15. YuSeung Law, Chris Wong, Jeffrey Turner, Alexis A. Gonzalez, Minolfa C Prieto, Graham Forsyth Wagner. VASOPRESSIN CONTROLS STANNIOCALCIN-1 GENE EXPRESSION IN RAT AND MOUSE KIDNEY. Molecular and Cellular Endocrinology; 348(1):183-188, 2012.

Recent Publications: A PubMed listing of research publications for Minolfa Prieto, M.D., Ph.D.

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