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lisa04


Lisa M. Harrison-Bernard, PhD
Associate Professor of Physiology,
Louisiana State University Health Sciences Center

Ph.D.: Tulane University
Postdoctoral Training: Tulane University School of Medicine, 1990-1994

 



hr Research Interests:
Major Focus:  Renin-Angiotensin System, Renal Microcirculatory Physiology, Angiotensin Receptor Regulation, Hormonal Regulation of the Renal Microcirculation, Role of the Renin-Angiotensin System in Blood Pressure Regulation, Interaction of Angiotensin II and Nitric Oxide on Renal Function, Mechanisms of Renal Blood Flow Autoregulation

Research focuses on the assessment of the functional and molecular mechanisms linking the physiology of hypertension with the altered expression of critical components of the renin angiotensin system - angiotensinogen, angiotensin converting enzyme, renin, and the angiotensin type 1 receptor. The role of the renin angiotensin system in controlling the renal microvasculature tone is a specific area of research. The regulation of both the function (vasoconstriction) and expression (mRNA and protein) of the angiotensin receptor in the renal vasculature is performed following chronic manipulation of circulating angiotensin II levels in mouse gene knockout models for the two subtypes of the angiotensin type one receptors, AT1A and AT1B. Another area of interest focuses on understanding the intrinsic properties of the kidney which control renal blood flow and glomerular filtration rate within a narrow range during large fluctuations in arterial pressure. The rat and mouse renal microcirculations are studied using the in vitro blood perfused juxtamedullary nephron technique. This system allows the direct measurement of vessel diameter single renal microvessels in both the cortical and medullary circulations.

hr

Recent Publications:

A PubMed listing of research publications for Lisa M. Harrison-Bernard, Ph.D.

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Contact:

Department of Physiology
Medical Education Building (MEB)
Box P7-3, Room 7213
1901 Perdido Street
New Orleans, Louisiana 70112-1393
Direct Office Phone: (504) 568-6175
Main Office Phone: (504) 568-6171
Main Office Fax: (504) 568-6158
E-mail: lharris@lsuhsc.edu
Web Page Address: www.lsuhsc.edu
 

Tulane University, New Orleans, LA 70118 504-865-5000 website@tulane.edu