Khalid Matrougui, PhD
Phone: (504) 988-2588
Room #: 4008
Ph.D.: University of Paris VIII, France; 1999
Project 1: Vascular dysfunction in Type 2 Diabetes:
Coronary arteriolar function is highly dependent on the integrity of endothelial cells (EC) and vascular smooth muscle cells (VSMC). My research is focus on studying signal transduction mechanisms in the vasculature (coronary arterioles and mesenteric resistance arteries), with special interest on defining the mechanisms by which cells in the vascular wall respond to hemodynamic and hormonal stimuli in physiological and pathological conditions (type 2 diabetes). We use in vivo studies, intact arteries, endothelial cells and smooth muscle cells culture to assess the contribution of nitric oxide, prostaglandins, epidermal growth factor receptor (EGFR), inflammatory cytokines (TNF-alpha), MAP-Kinases, JAK-STAT, PARP-1, NFkB), and reactive oxygen species in the regulation of vascular reactivity and structural, and blood pressure.
Project 2: Vascular endothelial dysfunction and aneurysm in hypertension:
The CD4+CD25+ regulatory T cell (Tregs) population is widely accepted as an important component of the immune system. Tregs play an indispensable role in maintaining self-tolerance and protection from autoimmune diseases as well as influencing immune responses to different pathogens. We are interested on relationship between immune system, inflammation, endothelial dysfunction and aneurysm in hypertension. We are especially interested on how CD4+CD25+ regulatory T cells and inflammation are involved in hypertension, vascular endothelial dysfunction and aneurysm, with special focus on TNF-alpha, NFkB, PARP-1 and endoplasmic reticulum stress pathways.
Project 3: Neovascularization in Type 2 Diabetes:
Our interest focuses on the role of stem cells, sodium nitrate, reticulum endoplasmic stress, epidermal growth factor receptor, PARP- 1, NFkB and MAP-kinase in impaired-ischemia neovascularization in type 2 diabetes.
- Soo-Kyoung Choi, PhD – Postdoctoral Fellow
- Maria Galan Arroyo, PhD – Postdoctoral Fellow
- Modar Kassan, PhD – Postdoctoral Fellow
- Amin A, Choi SK, Galan M, Kassan M, Partyka M, Kadowitz P, Henrion D, Trebak M, Belmadani S, Matrougui K. Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischemia-induced vascular pathology in type II diabetic mice. J Pathol. 2011 Nov 14. doi: 10.1002/path.3960.
- Choi SK, Galán M, Partyka M, Trebak M, Belmadani S, Matrougui K. Chronic inhibition of epidermal growth factor receptor tyrosine kinase and extracellular signal-regulated kinases 1 and 2 (ERK1/2) augments vascular response to limb ischemia in type 2 diabetic mice. Am J Pathol. 2012 Jan;180(1):410-8.
- Kassan M, Galan M, Partyka M, Trebak M, Matrougui K. Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2534-42.
- Zhang W, Halligan KE, Zhang X, Bisaillon JM, Gonzalez-Cobos JC, Motiani RK, Hu G, Vincent PA, Zhou J, Barroso M, Singer HA, Matrougui K, Trebak M. Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury. Circ Res. 2011 Aug 19;109(5):534-42.
Recent Publications: A PubMed listing of research publications for Khalid Matrougui, Ph.D.