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Dept. of Pharmacology, 8683
School of Medicine
Tulane University
1430 Tulane Ave
New Orleans, LA 70112
tel
504-988-5444 or 800-347-5935
fax
504-988-5283
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Infectious Disease Block Objectives

 

 

Antibiotics - Overview (Dery)

By the end of the session you should be able to:

  1. Discuss the process of choosing the correct antibiotic.
  2. Discuss the process of identifying the infecting organism.
  3. Describe the time dependent and concentration dependent pharmacokinetic/pharmacodynamic of antibiotics.
  4. Describe how to determine the antimicrobial susceptibility of infecting organisms (the MIC).
  5. Describe the host factors necessary to understand so that the correct antibiotic is chosen.
  6. Describe the mechanisms of action for the antimicrobial drugs & drug classes listed below
  7. Describe the mechanisms of resistance for the antimicrobial drugs discussed.
  8. Describe the D test and what information can be learned from it.

Drug List:   

  • Penicillins: penicillin G, penicillin V, methicillin, oxacillin, nafcillin, dicloxacillin, ampicillin, amoxicillin, ticarcillin, piperacillin
  • Cephalosporins: cephalexin, cefazolin, cefuroxime, cefoxitin, cefotetan, cefaclor, cefotaxime, ceftriaxone, ceftazidime, cefixime, cefepime
  • Monobactams: aztreonam
  • Carbapenems: doripenem, ertapenem, meropenem, imipenem (& imipenem + cilastatin)
  • Beta-Lactamase Inhibitors: clavulanic acid, sulbactam, tazobactam
  • Macrolides: erythromycin, clarithromycin, azithromycin;
  • Tetracyclines: tetracycline, doxycycline, minocycline
  • Fluoroquinolones: ciprofloxacin, levofloxacin, moxifloxacin
  • Aminoglycosides: amikacin, gentamicin, kanamycin, neomycin, netilmicin, streptomycin, tobramycin
  • Urinary Antiseptic: nitrofurantoin
  • Polymyxins: colistin, colistimethate, polymyxin B
  • Clindamycin
  • Metronidazole
  • Rifamycins: rifampin, rifabutin
  • Sulfonamides: trimethoprim-sulfamethoxazole, sulfadiazine
  • Glycopeptides: vancomycin, telavancin, teicoplanin
  • Membrane Active Agents: daptomycin
  • Oxazolidinones: linezolid
  • Streptogramins: quinupristin/dalfopristin (combination)

Antifungal Drugs (Mondal)

  1. List the antifungal drugs useful in treatment of fungal infections.
  2. Explain the mechanism of action of each of these drugs.
  3. Compare the pharmacokinetic properties of various antifungals.
  4. Describe the major therapeutic indications of each of these drugs.
  5. List the adverse effects associated with the antifungal drugs.
  6. Know the liposomal preparations of Amphotericin B.
  7. Be aware of the antifungal drug interactions, e.g. with warfarin.

Drug List:  
Amphotericin-B, Nystatin, Ketoconazole, Fluconazole, Itraconazole, Voriconazole, Miconazole, Ravuconazole, Terbinafine, Griseofulvin, Flucytosine, Caspofungin, Micafungin & Anidulafungin




Antiviral Drugs: non-HIV (Mondal)

By the end of the session you should be able to:

  1. Classify antiviral drugs based upon their site of inhibition in the viral replication cycle.
  2. Explain their mechanisms of action.
  3. Describe their major therapeutic indications.
  4. Compare their pharmacokinetic properties.
  5. List their adverse side effects and potential drug interactions.
  6. Explain the factors that regulate antiviral drug resistance.

Drug List:

Amantadine, Rimantadine, Zanamavir, Oseltamivir
Idoxuridine, Trifluridine
Acyclovir, Valacyclovir, Ganciclovir, Valganciclovir
Foscarnet, Ribavirin, Interferon α-2b
Lamivudin, Adefovir

1430 Tulane Avenue, SL-83, New Orleans, LA 70112 504-988-5444 cclarks@tulane.edu