Role of Rad in abdominal aortic aneurysms (AAA)
Ras associated with diabetes (Rad), a member of the RGK small G protein family, is known to be decreased in patients suffering from heart failure. Furthermore, Rad plays an important role against the development of cardiac hypertrophy and myocardial fibrosis. However, the function of Rad in the vasculature is unclear. Moreover, the physiological and pathophysiological roles of Rad in abdominal aortic aneurysms (AAA) have not been previously studied. The long-term objectives of our laboratory are to gain a better understanding into the role of Rad in the progression and rupture of AAA and identify key target genes that could serve as potential candidates for therapeutic targets against AAA. Next, we will conduct an in-depth investigation of any potential Rad-mediated signaling mechanisms that may result in attenuation of AAA. With an anticipated rise in AAA prevalence, there has been an increase in current research to develop novel pharmacological treatments aimed at reducing AAA development and progression. These studies will provide insight into the feasibility of Rad as a therapeutic drug target.
Department of Pharmacology SL83, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112-2699. tel 504-988-1795; fax 504-988-5283. e-mail: email@example.com
Pubmed listing of Dr. Hamblin's research publications.
1430 Tulane Avenue, SL-83, New Orleans, LA 70112 504-988-5444 firstname.lastname@example.org