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Hematopathology — Image #47 — Metastases to Bone Marrow

Carcinoma Metastatic to Bone Marrow

Low Power H&E of Metastatic Carcinoma to Bone Marrow:

Low Power H&E of Metastatic Carcinoma to Bone Marrow

 

Cytokeratin Stain of Carcinoma Metastatic to Bone Marrow:

Cytokeratin Stain of Carcinoma Metastatic to Bone Marrow

Many carcinomas can metastasize to bone marrow, notably breast, lung, thyroid, kidney, and prostate. Carcinoma cells may announce their presence in marrow by a desmoplastic reaction, or sneak in almost imperceptibly with scattered cells only slightly larger than the hematopoietic cells. Special stain for cytokeratin is helpful; here the metastatic cells are clearly highlighted. Bone marrow involvement counts as "distant mets" in staging and indicates a high stage tumor.

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