Infiltrates of epithelioid histiocytes contain folded or indented nuclei. Eosinophils are intermixed. Most cases occur in childhood and may be associated with development of lymphoma or acute lymphoblastic leukemia. Infection, solvent exposure, and lack of vaccination are postulated etiologies. In adults who smoke, this disorder in the lung may represent a reactive process rather than a neoplastic one, as it may resolve with cessation of smoking.
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