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Hematopathology — Image #42 — Mycosis Fungoides—Sezary Syndrome

Upper Dermal Infiltrate:

Upper Dermal Infiltrate

Close-up View (notice epidermal migration of atypical lymphocytes):

Upper Dermal Infiltrate Close-Up

CD3 Staining:

CD3 Staining

 

Sezary Cells "Cellules Monstreuses":

Sezary Cells

Sezary cells are neoplastic T4 cells (rare cases are T8) that target the epidermis and may circulate in blood. Patients present with erythroderma, cutaneous plaques, or nodules, and usually have a prolonged course. The images show the atypical cells accumulating in the upper dermis, migrating into the epidermis, staining with anti-CD (T-cell), and circulating as very large, bizarre Sezary cells called "cellules monstreuses." Cell morphology varies patient to patient, but generally is a large cell with a large, basophilic, convoluted nucleus and relatively scant cytoplasm, occasionally with a necklace of vacuoles around the nucleus. Phototherapy, chemotherapy, and radiation may be used for treatment.

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