At low power you can see how the normal architecture of the lymph node has been completely effaced by the lymphoma. Close-up, the neoplastic lymphocytes are large, with a large irregular nucleus and coarse chromatin. Mitotic figures are easily found. This lymphoma may occur de novo, or as an advanced phase of a pre-existing B-cell lymphoma such as follicular or monocytoid types. These are aggressive lymphomas requiring prompt treatment.
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