These cells constitute only up to 1% of the blood white cells. They are similar in size to a mature neutrophil. The granules are quite large, deep purple, and obscure the nucleus. Cytoplasm appears clear or slightly tinted pink. The granules contain histamine, heparin, and other compounds that are vasoactive and chemoattractant. Finding no basophils in a blood count is of no clinical significance. Too many may reflect drug reactions. Higher increases are associated with chronic myeloid leukemia.
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