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Tulane University Health Sciences
Department of Pathology and Laboratory Medicine
1430 Tulane Avenue SL-79
New Orleans, Louisiana
70112-2699
Phone 504-988-5224
Fax 504-988-7389
Email tulpath@tulane.edu

Zhen Lin, MD, PhD

Zhen Lin, Ph.D.

Assistant Professor of Pathology


Office Address:

Tulane University Health Sciences Center
Louisiana Cancer Research Center
Department of Pathology, SL-79
New Orleans, LA 70112
Phone: 504-988-1169
Fax: 504-988-5516
Email: zlin@tulane.edu




Education:

1995-2000

M.D.

Peking University Health Science Center, School of Medicine, Beijing, China

2000-2005

Ph.D.

Tulane University, New Orleans, Louisiana (Molecular and Cellular Biology)




Postgraduate Training and Fellowship Appointments:

2005-2007

Postdoctoral Researcher
Tulane University School of Medicine, New Orleans, LA
(Viral Oncology)

   


Faculty Appointments:

2007-Present

Assistant Professor of Pathology

Tulane University School of Medicine, New Orleans, LA

 


Awards, Honors, and Memberships in Honor Societies:

2003

Tulane Cancer Center Award for Cancer Research.

2005

Morris F. Shaffer and Margaret H.D. Smith Shaffer Award for Excellence in Research,
Tulane University

Sigma Xi (Full membership)




Membership in Professional and Scientific Societies:

American Association for Cancer Research (Active/Full membership)

American Society for Microbiology

American Association for the Advancement of Science


Reviewer (Projects):

Grant Reviewer:

Invited grant reviewer for Pennsylvania Department of Health Research on Cancer Diagnostics or Therapeutics with Commercialization Potential-Therapeutics for Universities (2012)

Referee Panel, Health and Medical Research Fund (HMRF), Food and Health Bureau, Hong Kong SAR, China (2012-present)

Invited grant reviewer for Pennsylvania Department of Health Pennsylvania Formula Grant Review-12-13 Cycle B (2013).

Invited grant reviewer for Pennsylvania Department of Health Pennsylvania Formula Grant Review-12-13 Cycle C (2013).

Invited grant reviewer for Pennsylvania Department of Health Pennsylvania Formula Grant Review-14-15 Cycle B (2014).

Invited grant reviewer for Florida Department of Health James and Esther King Biomedical Research Program and Bankhead-Coley Cancer Research Program Grant Review (2015).


Journal Reviewer:

PLoS Pathogens
Journal of Virology
Virology
The International Journal of Biochemistry & Cell Biology
PLoS ONE
Journal of Cellular Biochemistry PLoS ONE
International Journal of Cancer
Current Drug Targets
Anti-Cancer Agents in Medicinal Chemistry
E-Biomedicine
OcoTargets and Therapy
Journal of Biorepository Science for Applied Medicine
Austin Journal of Medical Oncology
Journal of Innovative Optical Health Sciences
Evidence-Based Complementary and Alternative Medicine


Book Reviewer:

Cancer Prevention and Treatment (2006)



Research Funding

(1) Active Funding:

As Principal Investigator:
"Analysis of the pathogenesis of HIV/EBV associated DLBCL"
Principal Investigator: Zhen Lin
Type: LA CaTS Pilot Grant
Agency: Louisiana Clinical and Translational Science Center (LA CaTS)
NIH Institutional Development Award Program for Clinical and Translational Research (IdeA-CTR) grant (1 U54 GM104940)



Bibliography

Selected Peer-Reviewed Journals:

Most recent (2010 to present):

Subing Cao, Walter Moss, Christine O'Grady, Monica Concha, Michael Strong, Xia Wang, Yi Yu, Melody Baddoo, Kun Zhang, Claire Fewell, Zhen Lin, Yan Dong, and Erik Flemington. New non-coding lytic transcripts derived from the Epstein Barr virus latency origin of replication oriP are hyper-edited, bind the paraspeckle protein, NONO/p54nrb, and support lytic viral transcription. In Press. Journal of Virology. 2015

Cao S, Strong MJ, Wang X, Moss WN, Concha M, Lin Z, O'Grady T, Baddoo M,Fewell C, Renne R, Flemington EK. High-Throughput RNA sequencing based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project. J Virol. 2015 Jan;89(1):713-29.

Strong MJ, Xu G, Morici L, Splinter Bon-Durant S, Baddoo M, Lin Z, Fewell C,Taylor CM, Flemington EK. Microbial contamination in next generation sequencing: implications for sequence-based analysis of clinical samples. PLoS Pathog. 2014 Nov 20;10(11):e1004437.

Strong MJ, Lin Z, Flemington EK. Expanding the conversation on high-throughput virome sequencing standards to include consideration of microbial contamination sources. MBio. 2014 Oct 28;5(6).

Strong MJ, Baddoo M, Nanbo A, Xu M, Puetter A, Lin Z*. Comprehensive RNA-seq analysis reveals contamination of multiple nasopharyngeal carcinoma cell lines with HeLa cell genomes. J Virol. 2014 Sep; 88(18):10696-704. (* Corresponding author).

O'Grady T, Cao S, Strong MJ, Concha M, Wang X, Splinter Bondurant S, Adams M, Baddoo M, Srivastav SK, Lin Z, Fewell C, Yin Q, Flemington EK. Global bidirectional transcription of the Epstein-Barr virus genome during reactivation. J Virol. 2014 Feb;88(3):1604-16.

Strong MJ, O'Grady T, Lin Z, Xu G, Baddoo M, Parsons C, Zhang K, Taylor CM, Flemington EK. Epstein-Barr virus and human herpes virus 6 detection in a non-Hodgkin's diffuse large B-cell lymphoma cohort by using RNA sequencing. J Virol. 2013 Dec;87(23):13059-62.

Sides MD, Sosulski ML, Luo F, Lin Z, Flemington EK, Lasky JA. Co-treatment with arsenic trioxide and ganciclovir reduces tumor volume in a murine xenograft model of nasopharyngeal carcinoma. Virol J. 2013 May 16;10(1):152.

Strong MJ, Xu G, Coco J, Baribault C, Vinay DS, Lacey MR, Strong AL, Lehman TA, Seddon MB, Lin Z, Concha M, Baddoo M, Ferris M, Swan KF, Sullivan DE, Burow ME, Taylor CM, Flemington EK. Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant Therapy. PLoS Pathog. 2013 May;9(5):e1003341.

Lin Z, Wang X, Strong MJ, Concha M, Baddoo M, Xu G, Baribault C, Fewell C, Hulme W, Hedges D, Taylor CM, Flemington EK. Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains. J Virol. 2013 Jan;87(2):1172-82.

Li C, Nguyen HT, Zhuang Y, Lin Z, Flemington EK, Zhuo Y, Kantrow SP, Morris GF, Sullivan DE, Shan B. Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene. 2012 Dec 15;511(2):143-50.

Lin, Z., Puetter, A., Coco, J., Xu, G., Strong, M.J., Wang, X., Fewell, C., Baddoo, M., Taylor, C., and Flemington, E.K. Detection of murine leukemia virus in the Epstein-Barr virus-positive human B-cell line JY, using a computational RNA-Seq-based exogenous agent detection pipeline, PARSES. J Virol. 2012 86 (6), 2970-2977.

Nguyen HT, Li C, Lin Z, Zhuang Y, Flemington EK, Burow ME, Lin Y, Shan B. (2012) The microRNA expression associated with morphogenesis of breast cancer cells in three- dimensional organotypic culture. Oncol Rep. 28(1):117-26.

Concha M, Wang X, Cao S, Baddoo M, Fewell C, Lin Z, Hulme W, Hedges D, McBride J, Flemington EK. Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-seq. J Virol. 2012 86(3): 1458-1467.

Lin, Z., and E. K. Flemington. 2011. miRNAs in the pathogenesis of oncogenic human viruses. Cancer Lett 305:186-99.

Sides, M. D., G. J. Block, B. Shan, K. C. Esteves, Z. Lin, E. K. Flemington, and J. A. Lasky. 2011. Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. Virology 416:86-97.

Sides, M. D., R. C. Klingsberg, B. Shan, K. A. Gordon, H. T. Nguyen, Z. Lin, T. Takahashi, E. K. Flemington, and J. A. Lasky. 2011. The Epstein-Barr Virus Latent Membrane Protein 1 and Transforming Growth Factor-{beta}1 Synergistically Induce Epithelial-Mesenchymal Transition in Lung Epithelial Cells. Am J Respir Cell Mol Biol 44:852-62.

Lin, Z., X. Wang, C. Fewell, J. Cameron, Q. Yin, and E. K. Flemington. 2010. Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member miR-429. J Virol 84:7892-7.

Lin, Z., G. Xu, N. Deng, C. Taylor, D. Zhu, and E. K. Flemington. 2010. Quantitative and qualitative RNA-Seq-based evaluation of Epstein-Barr virus transcription in type I latency Burkitt's lymphoma cells. J Virol 84:13053-8.

Yin, Q., X. Wang, C. Fewell, J. Cameron, H. Zhu, M. Baddoo, Z. Lin, and E. K. Flemington. 2010. MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP- mediated Epstein-Barr virus reactivation. J Virol 84:6318-27.

Xu, G., C. Fewell, C. Taylor, N. Deng, D. Hedges, X. Wang, K. Zhang, M. Lacey, H. Zhang, Q. Yin, J. Cameron, Z. Lin, D. Zhu, and E. K. Flemington. 2010. Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA 16:1610-22.

Book Chapter:

Zhen Lin and Erik K. Flemington, Regulation of EBV latency by viral lytic proteins. In: Erle S. Robertson, Editor, Epstein-Barr virus: latency and transformation, Caister Academic Press, London, England. (2010) : 167-192.

Dept. of Pathology & Laboratory Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 504-988-5224 tulpath@tulane.edu