shadow_tr

Zhen Lin, PhD

Zhen Lin, Ph.D.


Research Assistant Professor


Office Address:

Tulane University Health Sciences Center Department of Pathology, SL-79
New Orleans, LA 70112
Phone: 504-988-1169
Fax: 504-988-5516
Email: zlin@tulane.edu




Education:

1995-2000

M.D.

Peking University Health Science Center, School of Medicine, Beijing, China

2000-2005

Ph.D.

Tulane University, New Orleans, Louisiana (Molecular and Celular Biology)




Postgraduate Training and Fellowship Appointments:

2005-2007

Postdoctoral Researcher
Tulane University School of Medicine, New Orleans, LA

   


Faculty Appointments:

2007-Present

Research Assistant Professor of Pathology

Tulane University School of Medicine, New Orleans, LA

 


Awards, Honors, and Memberships in Honor Societies:

2003

Tulane Cancer Center Award for Cancer Research.

2005

Morris F. Shaffer and Margaret H.D. Smith Shaffer Award for Excellence in Research,
Tulane University




Membership in Professional and Scientific Societies:

American Association for Cancer Research

American Society for Microbiology

American Association for the Advancement of Science


Reviewer (Projects):

Grant Reviewer:

Invited grant reviewer for Pennsylvania Department of Health Research on Cancer Diagnostics or Therapeutics with Commercialization Potential-Therapeutics for Universities (2012)

Referee Panel, Health and Medical Research Fund (HMRF), Food and Health Bureau, Hong Kong SAR, China (2012-present)

Invited grant reviewer for Pennsylvania Department of Health Pennsylvania Formula Grant Review-12-13 Cycle B (2013).

Invited grant reviewer for Pennsylvania Department of Health Pennsylvania Formula Grant Review-12-13 Cycle C (2013).


Journal Reviewer:

PLoS Pathogens
Journal of Virology
Journal of Cellular Biochemistry PLoS ONE
International Journal of Cancer
Virology

Book Reviewer:

Cancer Prevention and Treatment (2006)



Bibliography

Selected Peer-Reviewed Journals:

Most recent (2010 to present):

1. Sides MD, Sosulski ML, Luo F, Lin Z, Flemington EK, Lasky JA. Co-treatment with arsenic trioxide and ganciclovir reduces tumor volume in a murine xenograft model of nasopharyngeal carcinoma. Virol J. 2013 May 16;10(1):152.

2. Strong MJ, Xu G, Coco J, Baribault C, Vinay DS, Lacey MR, Strong AL, Lehman TA, Seddon MB, Lin Z, Concha M, Baddoo M, Ferris M, Swan KF, Sullivan DE, Burow ME, Taylor CM, Flemington EK. Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant Therapy. PLoS Pathog. 2013 May;9(5):e1003341.

3. Lin Z, Wang X, Strong MJ, Concha M, Baddoo M, Xu G, Baribault C, Fewell C, Hulme W, Hedges D, Taylor CM, Flemington EK. Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus strains. J Virol. 2013 Jan;87(2):1172-82.

4. Li C, Nguyen HT, Zhuang Y, Lin Z, Flemington EK, Zhuo Y, Kantrow SP, Morris GF, Sullivan DE, Shan B. Comparative profiling of miRNA expression of lung adenocarcinoma cells in two-dimensional and three-dimensional cultures. Gene. 2012 Dec 15;511(2):143-50.

5. Lin, Z., Puetter, A., Coco, J., Xu, G., Strong, M.J., Wang, X., Fewell, C., Baddoo, M., Taylor, C., and Flemington, E.K. Detection of murine leukemia virus in the Epstein-Barr virus-positive human B-cell line JY, using a computational RNA-Seq-based exogenous agent detection pipeline, PARSES. J Virol. 2012 86 (6), 2970-2977.

6. Nguyen HT, Li C, Lin Z, Zhuang Y, Flemington EK, Burow ME, Lin Y, Shan B. (2012) The microRNA expression associated with morphogenesis of breast cancer cells in three- dimensional organotypic culture. Oncol Rep. 28(1):117-26.

7. Concha M, Wang X, Cao S, Baddoo M, Fewell C, Lin Z, Hulme W, Hedges D, McBride J, Flemington EK. Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-seq. J Virol. 2012 86(3): 1458-1467.

8. Lin, Z., and E. K. Flemington. 2011. miRNAs in the pathogenesis of oncogenic human viruses. Cancer Lett 305:186-99.

9. Sides, M. D., G. J. Block, B. Shan, K. C. Esteves, Z. Lin, E. K. Flemington, and J. A. Lasky. 2011. Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. Virology 416:86-97.

10. Sides, M. D., R. C. Klingsberg, B. Shan, K. A. Gordon, H. T. Nguyen, Z. Lin, T. Takahashi, E. K. Flemington, and J. A. Lasky. 2011. The Epstein-Barr Virus Latent Membrane Protein 1 and Transforming Growth Factor-{beta}1 Synergistically Induce Epithelial-Mesenchymal Transition in Lung Epithelial Cells. Am J Respir Cell Mol Biol 44:852-62.

11. Lin, Z., X. Wang, C. Fewell, J. Cameron, Q. Yin, and E. K. Flemington. 2010. Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member miR-429. J Virol 84:7892-7.

12. Lin, Z., G. Xu, N. Deng, C. Taylor, D. Zhu, and E. K. Flemington. 2010. Quantitative and qualitative RNA-Seq-based evaluation of Epstein-Barr virus transcription in type I latency Burkitt's lymphoma cells. J Virol 84:13053-8.

13. Yin, Q., X. Wang, C. Fewell, J. Cameron, H. Zhu, M. Baddoo, Z. Lin, and E. K. Flemington. 2010. MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP- mediated Epstein-Barr virus reactivation. J Virol 84:6318-27.

14. Xu, G., C. Fewell, C. Taylor, N. Deng, D. Hedges, X. Wang, K. Zhang, M. Lacey, H. Zhang, Q. Yin, J. Cameron, Z. Lin, D. Zhu, and E. K. Flemington. 2010. Transcriptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA 16:1610-22.

Book Chapter:

1. Zhen Lin and Erik K. Flemington, Regulation of EBV latency by viral lytic proteins. In: Erle S. Robertson, Editor, Epstein-Barr virus: latency and transformation, Caister Academic Press, London, England. (2010) : 167-192.

 

Dept. of Pathology & Laboratory Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 504-988-5224 tulpath@tulane.edu