shadow_tr

Welcome

Education

Research

Clinical Services

Personnel

Conferences

Annual Lectureships

News


Tulane University Health Sciences
Department of Pathology and Laboratory Medicine
1430 Tulane Avenue SL-79
New Orleans, Louisiana
70112-2699
Phone 504-988-5224
Fax 504-988-7389
Email tulpath@tulane.edu

Erik K. Flemington, PhD

Erik K. Flemington, Ph.D.

 

PROFESSOR

 

Postdoctoral Training

1987-1990     Research Fellow, Department of Pathology, Dana-Farber
                      Cancer Institute and Harvard Medical School.

Academic Appointments

1990 – 1995         Instructor in Pathology, Dana Farber Cancer Institute and
                             Harvard Medical School
1996 – 2000         Assistant Professor of Medicine, Harvard Medical School
                             and Dana-Farber Cancer Institute
2000 – 2007         Associate Professor of Pathology, Tulane Health Sciences
                             Center, Tulane Cancer Center
2008 – Present     Professor of Pathology, Tulane Health Sciences Center
2008 – Present     Program leader of Cancer Genetics Program,Tulane Cancer Center
2009 – Present     Zimmerman Endowed Professor of Cancer Research, Tulane Cancer Center.

 

Grant Review Panels

US ARMY Prostate cancer Award Program (2003 and 2005)
National Institutes of Health – Experimental Virology Study Section (2003)
National Institutes of Health – AIDS-associated Opportunistic Infections & Cancer Study Section (2003-2005)
National Institutes of Health – AARR-A Study Section (2005)
National Institutes of Health – AIDS-associated Opportunistic Infections & Cancer Study Section (2006-2009)
National Institutes of Health – ZRG1 AARR-C (2009)
National Institutes of Health – ZRG1 IDM-C (2009)
National Institutes of Health – ZRG1 AARR-K (April 2010)
National Institutes of Health – EDRN Biomarker Development Labs (U01) (May 2010)
National Institutes of Health – ZCA1 RPRB Basic and translational Molecular Oncology (P01) (January, 2011)
National Institutes of Health – AIDS-associated Opportunistic Infections & Cancer Study Section (July, 2011)
National Institutes of Health – AIDS-associated Opportunistic Infections & Cancer Study Section (March, 2012)
National Institutes of Health – ZCA1 RPRB-J (01) R NCI Program Project Study Section (June, 2012)
National Institutes of Health – ZRG1 AARR-K(03) AOIC conflicts review (July, 2012)
National Institutes of Health – NCI P01 SEP review meeting (October, 2012)
National Institutes of Health - ZRG1 AARR-C (04) SEP for AOIC and NAED (December, 2012)
National Institutes of Health – NCI Program Project Special Emphasis Panel (February, 2013)
National Institutes of Health – ZRG1 AARR-K (03) M (April, 2013)
National Institutes of Health – ZDE1 RK (18) 1 (June 18, 2013)
National Institutes of Health – ZRG1 AARR-K (02) M (August, 2013)
National Institutes of Health – AOIC (November, 2013)
National institutes of Health – NCI P01 SEP review meeting (February, 2014)


Editorial Boards

1993 – 2002  Editor, Analytical Biochemistry.

Journal Review Assignments

J Virol, Virol, Oncogene, PloS Pathogens, Journal of Biological Chemistry, Trends in Microbiology, Journal of Molecular Biology, Journal of Clinical Microbiology, J. General Virology.

Other Assignments

AIDS and Cancer Specimen Resource (ACSR) review panel.

 

U. S. Patents  

1) Approved:  US 5759803 – Retinoblastoma-Associated Protein 1 (E2F-1) Polypeptides and cDNA.
 

Selected Publications:

O’Grady, T, Cao, S, Strong, MJ, Concha, M, Wang, X, Splinter BonDurant, S, Adams, M, Baddoo, M, Srivastav, SK, Lin, Z, Fewell, C, Yin, Q, and Flemington, EK. Global bidirectional transcription of the Epstein-Barr virus genome during reactivation. J Virol. 2013; Nov 20 [Epub ahead of print] PMID: 24257595

Strong, MJ, O’Grady, T, Lin, Z, Xu, G, Baddoo, M, Parsons, C, Zhang, K, Taylor, CM, and Flemington, EK. Epstein-Barr Virus and Human Herpesvirus 6 Detection in a non-Hodgkin’s Diffuse Large B-Cell Lymphoma Cohort using RNA-Seq. J Virol. 2013; 87:13059-13062. PMID: 24049168

Strong, MJ, Xu, G, Coco, J, Baribault, C, Vinay, DS, Lacey, MR, Strong, AL, Lehman, TA, Seddon, MB, Lin, Z, Concha, M, Baddoo, M, Ferris, MB, Swan, KF, Sullivan, DE, Burow, ME, Taylor, CM and Flemington, EK. Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity; implications for possible immune adjuvant therapy. PLOS Pathogens 2013; 9: e1003341. PMID: 23671415

Lin, Z, Wang, X, Strong, MJ, Concha, M, Baddoo, M, Xu, G, Baribault, C, Fewell, C, Hulme, W, Hedges, D, Taylor, CM, Flemington, EK. Whole genome sequencing of the Akata and Mutu Epstein-Barr virus strains. J Virol. 2013; 87:1172-1182 PMID: 23152513.

Lin, Z, Puetter A, Coco J, Xu G, Strong, MJ, Wang, X, Fewell, C, Baddoo, M, Taylor CM, Flemington, EK. Detection of Murine Leukemia Virus in the Epstein-Barr Virus-Positive Human B-Cell Line JY, Using a Computational RNA-Seq-Based Exogenous Agent Detection Pipeline, PARSES. J Virol. 2012 Mar;86(6):2970-7. PMID:22238296.

Concha, M, Wang, X, Cao, S, Baddoo, M, Fewell, C, Lin, Z, Hulme, W, Hedges, D, McBride, J, Flemington, EK. Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-seq. J Virol. 2012 86:1458 (PMID: 22090128).

Lin, Z, and Flemington, EK. miRNAs in the pathogenesis of oncogenic human viruses. Cancer Letters, 2011; 305: 186-199 (PMID: 20943311)

Deng, N, Puetter, A, Zhang, K, Johnson, K Zhao, Z Taylor, CM, *Flemington, EK, *Zhu, D. Isoform-level microRNA-155 target prediction using RNA-seq. Nucl. Acids Res. 2011; 39:e61 (PMID: 21317189) (*corresponding authors)

Xu, G, Deng, N, Zhao, Z, Zhang, K, Judeh, T, Flemington, EK, Zhu, D. SAMMate: a GUI tool for processing short read alignments in SAM/BAM format. Source Code for Biology and Medicine. 2011; 6:2 (PMID: 21232146)

Lin, Z, Wang, X, Fewell, C, Cameron, J, Yin, Q, Flemington, EK. Differential expression of the miR-200 family microRNAs in epithelial and B-cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member, miR-429.  J. Virol. 2010; 84:7892-7897 (PMID: 20484493).

Lin, Z, Xu, G, Deng, N, Taylor, CM, Zhu, D, Flemington, EK. Quantitative and qualitative RNA-seq based evaluation of Epstein-Barr virus transcription in type I latency Burkitt’s lymphoma cells. J Virol 2010; 84:13053-13058 (PMID: 20943983).

Yin, Q, Wang, X, Fewell, C, Cameron, J, Zhu, H, Baddoo, M, Lin, Z, Flemington, EK. MiR-155 inhibits Bone Morphogenetic Protein (BMP) signaling and BMP mediated Epstein Barr virus reactivation. J Virol 2010; 84:6318-6327 (PMID: 20427544).

Xu, G, Fewell, C, Taylor, CM, Deng, N, Hedges, D, Wang, X, Zhang, K, Lacey, M, Zhang, H, Yin, Q, Cameron, J, Lin, Z, Zhu, D, Flemington, EK. Transcriptome and targetome analysis in miR-155 expressing cells using RNA-seq. RNA 2010; 16:1610-1622 (PMID: 20584899).

Molina-Privado I, Rodríguez-Martínez M, Rebollo P, Martín-Pérez D, Artiga MJ, Menárguez J, Flemington EK, Piris MA, Campanero MR. E2F1 expression is deregulated and plays an oncogenic role in sporadic Burkitt's lymphoma. Cancer Res. 2009; 69:4052-4058.

Alvaro-Blanco, J, Martinez-Gac, L, Calonge, E, Rodriguez-Martinez, M, Molina-Privado, I, Redondo, JM, Alcami, J, Flemington, EK, Campanero, MR. A novel factor distinct from E2F mediates c-Myc promoter activation through its E2F element during exit from quiensence. Carcinogenesis 2009; 30:440-448.

Cameron, JE, Fewell, C, Yin, Q, McBride, J, Wang, X, Lin, Z, Flemington, EK. Differential expression of cellular microRNAs in EBV infected cells expressing type III vs type I latency genes. Virology 2008; 105:257-266.

Lin, Z, Fewell, C, Baddoo, M, McBride, J, and Flemington, EK. Complex regulation of EBV Zta ubiquitination. J Virol 2008; In Revision.

Oskowitz, AZ, Lu, J, Penfornis, P, Ylostalo, J, McBride, J, Flemington, EK, Prockop, D, and Pochampally, R. Human Multipotent Stromal Cells from Bone Marrow (hMSCs) and microRNA (miRNA): Regulation of Differentiation and Leukemia Inhibitory Factor Expression. PNAS 2008; 105:18372-18377.

Yin, Z, McBride, J, Fewell, C, Lacey, M, Wang, X, Lin, Z, Cameron, J, and Flemington, EK. microRNA-155 is an Epstein Barr virus induced gene that modulates Epstein Barr virus regulated gene expression pathways. J Virol. 2008; 82:5295-5306.

Yin, Z, Wang, X, McBride, J, Fewell, C, and Flemington, EK. B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. J Biol. Chem. 2008; 283: 2654-2662.

Cameron, JE, Yin, Q, Fewell, C, Lacey, M, McBride, J, Wang, X, Lin, Z, Schaefer, BC, and Flemington, EK. The Epstein-Barr virus latent membrane protein 1 (LMP1) induces cellular microRNA-146a, a modulator of lymphocyte signaling pathways. J Virol. 2008; 82: 1946-1958.


Book Chapters:

Flemington, EK, and Rodriguez, A. Use of Gene Overexpression to assess Function in Cell Cycle Control. In Cell Cycle Checkpoint Control Protocols. (Ed. Lieberman, H) Methods in Molecular Biology 2004; 241:195-206.

Lin, Z, and Flemington, EK. Regulation of EBV latency by viral lytic proteins. In Epstein-Barr Virus Latency and Transformation. (Ed. Erle S. Robertson) Horizon Press: In press

 

Research Support:

As Principal Investigator


“Role of the cellular microRNA, miR-155, in EBV type III signaling”
Principal Investigator: Erik K Flemington
Type: R01
Agency: NIH [R01CA138268]
Period: July 1, 2009 – June 31, 2014


“Intercellular communication in Epstein Barr virus reactivation”
Principal Investigator: Erik K Flemington
Type: R01
Agency: NIH [R01AI101046]
Period: April 1, 2012 to March 31, 2017

 

COBRE

“Mentoring a Program in Cancer Genetics"
Program Director:
Dr. Flemington is the Core Director and Mentor of administrative core for this grant.
Type: COBRE
Agency: NIH (P20 RR020152)
Period: August 1st, 2004 to July 31st 2014

 

As Collaborator

“Supramolecular Approaches to Protein Inhibitors Activated by MicroRNA-21”
Principal Investigator: Janarthanan Jayawickramarajah
Type: R01
Agency: NIH (R01 GM09757)
Period: April 1st, 2012 to March 31st, 2017

“Setting a trajectory: biological markers of early stress and child development”
Principal Investigator: Stacy Drury
Type: R01
Agency: NIH (MH101533)
Period: 08/01/2013 – 04/30/2018

Dept. of Pathology & Laboratory Medicine, 1430 Tulane Avenue, New Orleans, LA 70112 504-988-5224 tulpath@tulane.edu