- Bacterial Pathogenesis
- Studies of host-pathogen relationship during pulmonary infection
- Vaccine discovery and development against aerosol bacterial agents
Emerging infectious diseases and potential biological warfare agents represent a new and challenging obstacle in the field of medical microbiology. The majority of these pathogens, particularly the ?select agents?, can be transmitted through the aerosol route. My research interests focus on the host-pathogen relationship of bacterial organisms that are able to colonize and persist in the lung. In particular, we seek to identify novel mechanisms by which bacterial pathogens evade host immune surveillance and establish chronic infection in the host. Past studies of mine have focused on the capability of Mycobacterium tuberculosis to establish latency in lung granulomas and on the ability of Pseudomonas aeruginosa to persist in the cystic fibrosis lung. Currently, my laboratory is examining the molecular basis by which the biological threat agent, Burkholderia pseudomallei, evades host innate immune responses. We are using both proteomic and immunological approaches to identify novel surface proteins of B. pseudomallei that influence disease outcome through initial interactions with lung epithelial cells. In addition, we are applying these same techniques for the purposes of vaccine discovery and development against B. pseudomallei and other aerosol threat agents.
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Lisa Morici, Ph.D.
Department of Microbiology & Immunology
Tulane University Health Sciences Center
Tulane University, New Orleans, LA 70118 504-865-5000 firstname.lastname@example.org