Tulane Eosinophilic Disorder Center
The Tulane Center for Eosinophilia Disorders under the leadership of Dr. Anil Mishra is the first comprehensive center of its kind in the southern US. The center will provide an opportunity for researchers, patients and their families to understand the disease and receive better treatment of their eosinophil associated disorders. The center will also provide an opportunity for basic research scientists to directly translate their exciting new findings to afflicted patients with the help of a diverse clinician team. The center will be involved in basic, clinical and translational studies to determine the mechanistic aspects of eosinophilic disorders in the lung, skin and gastrointestinal tract. The center’s aim is to develop diagnostic and therapeutic interventions for eosinophilic diseases.
Eosinophilic disorders occur when eosinophils, white blood cells with a bilobed nucleus and multiple toxic granules, are found in increased numbers in various parts of the body. In the healthy state eosinophils reside in the gastrointestinal tract; however, during allergic (food or aeroallergen) responses, a large number of eosinophils are generated from their precursors in response to the stimulus and move into various organs of the body, where they release a variety of toxins that can cause chronic inflammation, which leads to organ damage.
Eosinophils have a critical role in promoting asthma, dermatitis, multiple gastrointestinal disorders and tissue remodeling (fibrosis).
We and other investigators have found that eosinophils play a major role in promoting asthma, dermatitis and a number of gastrointestinal diseases. We now have a better understanding of a number of allergic diseases because of our growing knowledge and better diagnostic technology. We are currently studying multiple novel compounds that block eosinophil production and their recruitment into various organs. Our research will lead to improved treatments for eosinophil-associated medical disorders such as asthma, eosinophilic dermatitis, eosinophil associated gastrointestinal disorders and tissue remodeling (fibrosis).
Asthma Fibrosis Eosinophilic esophagitis
Focus area of our research
Basic and Clinical Studies
Dr. Mishra’s general research is aimed at deciphering mechanisms of inflammation, and is primarily based on discoveries concerning innate immunity. In particular, gene-environment interactions in the elicitation of inflammatory states in the respiratory and gastrointestinal tracts are under investigation. Environmental triggers (such as aeroallergens and food allergens) are studied in the context of specific genetic variants (e.g. IL-15 and IL-18 signaling) using population studies (cross sectional and longitudinal prospective cohorts) and mechanism-driven studies. The biological properties of innate inflammatory cells (eosinophils, mast cells, NKT cells, epithelial cells) and the cytokines (especially chemokines) that mediate their function are under investigation. The contribution of these basic processes to diverse human inflammatory conditions (e.g. asthma, eosinophil associated gastrointestinal disorders) is pursued by translational studies often involving unique clinical resources (e.g. patient samples and databanks) and clinical intervention studies (e.g. anti-cytokine therapeutics).
Future clinical trials
Anil Mishra, PhD, Professor of Medicine and Edward G. Schlieder Educational Foundation Chair of Pulmonary Diseases, Director, Eosinophilic Disorder Center,
Members and Co-investigators:
Patients and Family
Patients and families are encouraged to contact our center for any information needed to understand the disease pathogenesis or treatment options for their eosinophil related disorders.
Tulane Eosinophilic Disorder Center
Funds needed for diagnostic and therapeutic interventions
Off Site Collaborative Partners and Consultants
1430 Tulane Ave, New Orleans, LA 70112 504-988-5187 email@example.com