Research in Nephrology encompasses studies ranging from basic science to clinical and epidemiology studies. The Nephrology Section collaborates with a variety of other departments and centers. Among these is the Department of Epidemiology in the School of Public Health, lead by Dr. Jiang He, in studying the epidemiology and genetics of chronic kidney disease and related cardiovascular diseases such as hypertension.
In addition, the Nephrology Section collaborates extensively with the Tulane Hypertension and Renal Center of Excellence and the Department of Physiology lead by Dr. Gabriel Navar. This group also includes Drs. Hiro Kobori, Kenneth Mitchell, Dewan Majid, and Kaillish Pandey, among others. These investigators study various aspects of the pathophysiology of hypertension, angiotensin II injury, and other hormones affecting cardiovascular physiology.
Below is a list of the research projects undertaken by the Nephrology & Hypertension Faculty.
View the Nephrology & Hypertension quarterly publications.
Dr. Nazih Nakhoul studies ammonia and acid-base transport. Currently he is investigating the role of Rh proteins and excretion of ammonium into the urine. This process is critical for acid-base homeostasis.
Dr. Jing Chen studies clinical and epidemiologic aspects of the progression of chronic kidney disease and the associated cardiovascular diseases. Her recent work has focused on the interrelationship of obesity, metabolic syndrome, endothelial dysfunction, adipocytokines, and inflammation with kidney and cardiovascular diseases. She is also doing research on the etiology of vascular calcification in patients with chronic kidney disease.
Dr. Vecihi Batuman studies the mechanisms whereby myeloma proteins and light chains cause kidney injury and how these may be positively affected by various agents such as PACAP. In addition, he has been involved in several studies of lead toxicity in the kidney.
Dr. Katie Hering-Smith studies the regulation of urinary citrate which is important in preventing kidney stones. Her work has shown a novel calcium-sensitive citrate reabsorbtive process in the kidney.
Dr. Lee Hamm studies various aspects of epithelial transport including that of ammonia and citrate. In addition, his laboratory studies how luminal proteases alter sodium transport and paracellular transport in the collecting duct. In addition, he is involved in clinical studies of chronic kidney disease and related co-morbidities.
Dr. Rubin Zhang studies clinical aspects of kidney and pancreas transplantation and the use of immunosuppressive therapies in this population.
Drs. Simon, Kleinpeter, Krane, and Alper are involved in a variety of clinical studies.
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