Endocrinology & Metabolism

Research

 A  variety of research resources are available in the Section of Endocrinology. A list of current studies is found below. These research projects and others through the Clinical Trials Cooperative provide numerous opportunities for research and scholarly publication, and are an integral part of the Endocrinology department. Publications relating to this research are found on our publications page. For more publications, please reference specific faculty or fellow pages.

Current Studies

GRADE: Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study

• SponsorNIH/NIDDK
• Principle Investigator: Dr. Fonseca
• Study dates: 12/12-9/20

D2d: Vitamin D to Prevent Type 2 Diabetes

• Sponsor:NIH/NIDDK
• Principle Investigator: Dr. Fonseca
• Study dates:2/12-12/17

Protocol #MSB-DM003 – "A Randomized, Placebo-Controlled, Dose-Escalation Study to Assess the Safety and Tolerability of a Single Intravenous Infusion of Allogeneic Mesenchymal Precursor Cells (MPCs) in Patients with Type 2 Diabetes Sub-optimally Controlled on Metformin"

• Sponsor:Mesoblast Inc
• Principle Investigator: Dr. Fonseca
• Study dates: 6/12-ongoing

Protocol #EFC11628 – "6-Month, Multicenter, Randomized, Open-label, Parallel-group Study Comparing the Efficacy and Safety of a New Formulation of Insulin Glargine and Lantus® both plus Mealtime Insulin in Patients with Type 2 Diabetes Mellitus with a 6-month Safety Extension Period"

• Sponsor: Sanofi-Aventis, U.S. Inc.
• Principle Investigator: Dr. Thethi
• Study dates: 6/12-ongoing

Protocol #EFC11629 – "6-Month, Multicenter, Randomized, Open-label, Parallel-group Study Comparing the Efficacy and Safety of a New Formulation of Insulin Glargine and Lantus® both in combination with oral antihyperglycemic drug(s) in Patients with Type 2 Diabetes Mellitus with a 6 month Safety Extension Period"

• Sponsor: Sanofi-Aventis, U.S. Inc.
• Principle Investigator: Dr. Thethi
• Study dates: 6/12-ongoing

ACCORDION: Action to Control Cardiovascular Risk in Diabetes Follow On.

• Sponsor: NIH
• Principal Investigator: Dr. Fonseca.
• Study Dates: 05/11-ongoing.

Basal Plus Trial: Basal Bolus versus Basal Insulin Regimen for the Treatment of Hospitalized Patients with Type 2 Diabetes Mellitus: A Randomized, Open Labeled, Non-Inferiority Controlled Study.

• Sponsor: Sanofi-Aventis.
• Principal investigator: Dr. Khan.
• Collabortion: Emory University
• Study dates:04/2010-ongoing.

Zemplar: Effect of Paricalcitol on Endothelial Function and Inflammation in Type 2 Diabetes and Chronic Kidney Disease.

• Sponsor: Scott & White Memorial Hospital.
• Principal Investigator: Dr. Fonseca
• Study dates: 04/2010-ongoing

LEADER: Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results A long-term, multi centre, international, randomized double-blind, placebo-controlled trial to determine liraglutide effects on cardiovascular events

• Sponsor: Novo Nordisk
• Principal Investigator: Dr. Thethi
• Study dates: 2011-2017

TECOS: A Randonmized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes after Treatment with Sitagliptin in Patients with Type 2 Diabetes Mellitus and Inadequate Glycemic Control.

• Sponsor: Merck, Inc.
• Principal Investigator: Dr. Khan.
• Collaboration: Duke Clinical Research Institute.
• Study dates: 05/2009-ongoing

BEACON: Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurance of Renal Events.

• Sponsor: Reata Pharmaceuticals, Inc.
• Principal Investigator: Dr. Fonseca.
• Study dates: 03/2011-ongoing

TINSAL-T2D: Targeting Inflammation Using Salsalate for Type 2 Diabetes.

• Sponsor: NIH
• Principal Investigator: Dr. Fonseca
• Collaboration: Joslin
• Study dates: 09/2006-ongoing

DRMS: Evaluation of a Diabetes Remote Monitoring and Management System.

• Sponsor: MedAdherence, LLC and Eli-Lilly, Inc.
• Principal Investigator: Dr. Fonseca
• Study dates: 07/2010-ongoing

Endocannabinoid: Endocannabinoids and Ethnic Variations in Obesity.

• Sponsor:Tulane Pilot Grant, Investigator Initiated.
• Principal Investigator: Dr. Thethi
• Study dates: 2009-ongoing

UFLC: Effect of Renin-Angiotensin-System Blockade on Urinary Free Light Chains in Patients with Type 2 Diabetes Mellitus.

• Sponsor:Tulane Pilot Grant, Investigator Initiated
• Principal Investigator: Dr. Thethi
• Study dates:2011-ongoing

Libra: The Effect of Detemir and Aspart Insulin on Intimal Hyperplasia Following Ballon Catheter Injury in Insulin Resistance and Early Diabetes (Zucker Fatty Rats).

• Sponsor:Novo-Nordisk
• Principal Investigator: Dr. Fonseca
• Study dates:2010-ongoing

Kaiser: Sub-Study of TINSAL-T2D Salsalate: A Diabetes Treatment for Carbonyl, Oxidative & Nitrosative Stress.

• Sponsor:NIH & Kaiser Foundation Research Institute.
• Co-Investigator: Dr. Fonseca
• Collaboration: Dr. Barzilay
• Study dates: 2010-ongoing

Stem Cell Research in Diabetes

• Sponsor: Tulane University Oliver Fund Scholar Award
• Principal Investigator: Dr. Fonseca
• Collaboration: Tulane Center for Stem Cell Research and Regenerative Medicine
• Study dates:2010-ongoing

Carbamylated Low-Density Lipoprotein and Cardiovascular Events.

• Sponsor: NIH
• Co-Investigator: Dr. Fonseca
• Collaboration: UAMS
• Study dates:2010-ongoing

Improving islet transplantation outcome with Akt1. Agency. (1R01DK081463)

• Sponsor: NIH NIDDK
• Principal Investigator: Dr. Wu
  
• Study dates: 04/01/2009 – 03/31/2014
  

ACCORD: Action to Control Cardiovascular Risk in Diabetes.

• Sponsor: NIH
• Principal Investigator: Dr. Fonseca
• Study dates: 2001-2009

Katrina: Katrina Impact on Diabetes

• Sponsor:Tulane, Investigator Initiated
• Study dates: 2006-2009