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Faculty

Jeffrey M. GimbleJeffrey M. Gimble, MD, PhD

Tulane University School of Medicine
Adjunct Professor, Department of Medicine and Surgery
Center for Stem Cell Research & Regenerative Medicine
E-mail: jgimble@tulane.edu

Adipose-derived stromal/stem cells in diabetes and obesity


Biography

Dr. Gimble is a physician-scientist with a clinical training in Medicine as well as a PhD in Cell Biology from Yale University. He completed his residency training at Washington University in St. Louis (Barnes Hospital) and his post-doctoral fellowship in the Laboratory of Immunogenetics at the National Institute for Allergy and Infectious Disease (Bethesda, MD). Prior to joining Tulane University Health Sciences Center, Dr. Gimble was respectively Assistant Member in the Immunobiology and Cancer Program at the Oklahoma Medical Research Foundation, an Associate Professor in the Department of Surgery at the University of Oklahoma Health Science Center (Oklahoma City, OK), Director of Tissue Engineering at Zen-Bio, Inc., Vice President of Tissue Engineering and Chief Scientific Officer at Artecel Sciences (Research Triangle Park NC), and Professor of Stem Cell Biology at Pennington Biomedical Research Center (Baton Rouge LA). He has co-authored over 170 publications dealing with the isolation, characterization, differentiation, and pre-clinical application of stromal/stem cells from adipose tissue and bone marrow. Dr. Gimble’s studies on metabolism and regenerative medicine using adipose stromal/stem cells have gained international attention. He is the principal investigator on research grants from the National Institutes of Health and the Department of Defense. He is a past president and current board member of the International Federation for Adipose Therapeutics and Science (IFATS). In addition to his academic appointment, he is the co-founder and Chief Scientific Officer of LaCell LLC, a biotechnology company housed within the New Orleans BioInnovation Center.

Ongoing research projects related to diabetes and obesity

For over a half century, cell based models have served a major role in research and discovery relating to adipose tissue function and pathology. While rodent models remain critical to investigations relating to diabetes and obesity, these animal models do not necessarily mimic human disease processes. Consequently, our Laboratory has focused on the isolation, characterization, and metabolism of primary human adipose-derived stromal/stem cells. By harvesting discarded human adipose tissue obtained from subjects undergoing elective surgeries, it has been possible to generate a biorepository of well characterized primary cultures representing a wide range of donor ages and body mass indices. We use cellular, molecular, pharmacological and regenerative medical approaches to explore the metabolism and regulation of human adipose stromal/stem cells (ASCs). Students and fellows are trained to gain a full understanding of the mechanisms underlying diabetes, obesity and osteoporosis at the stromal/stem cell level in adipose and bone tissues.

Ongoing projects include:

  1. Characterization and comparison of ASC and stromal vascular fraction cells isolated from subcutaneous and visceral adipose depots
  2. Development of tissue engineered adipose depots in murine models.
  3. Novel effects of estrogens in islet alpha-cells and preventing hyperglucagonemia.
  4. Proteomic analysis of serum biomarkers in orthopedic patients at risk for heterotopic ossification.
  5. Effect of phytoestrogens and synthetic selective estrogen receptor modulators (SERMs) on obesity, diabetes, and osteoporosis in ovariectomized rodent models.

Lab members:

Trivia Frazier PhD, Post-Doctoral Research Fellow
Elizabeth Martin, PhD, Post-Doctoral Research Fellow
Caasy Thomas-Porch, Graduate Student
Stephen Lee, Undergraduate Student
Connor Maccrimmon, Undergraduate Student

Other Links:

PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=gimble+j

 

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