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Faculty

Franck Mauvais-JarvisFranck Mauvais-Jarvis, MD, PhD

Tulane University School of Medicine
Professor, Department of Medicine, Section of Endocrinology
Director, Tulane Diabetes Research Program
E-mail: fmauvais@tulane.edu

Role of estrogen and androgen in diabetes and obesity



Biography

Dr. Mauvais-Jarvis is a physician-scientist with a clinical training in Medicine and Endocrinology as well as a PhD in Biochemistry and Molecular Biology from the University of Paris School of Medicine in France. He studied the mechanisms of insulin resistance as a Post-Doctoral Fellow at the Joslin Diabetes Center and Harvard Medical School. Prior to joining Tulane University Health Sciences Center in 2013, Dr. Mauvais-Jarvis was respectively Assistant Professor of Medicine at Baylor College of Medicine in Houston and Associate Professor of Medicine at Northwestern University Feinberg School of Medicine in Chicago. He has authored over 90 publications dealing with novel mechanisms and/or therapeutic perspectives for diabetes and obesity and the role of estrogen and androgens in these diseases. Dr. Mauvais-Jarvis is internationally renowned for his translational research on estrogen receptors activation in protecting pancreatic β-cells in diabetes. He is the principal investigator of research grants from the National Institutes of Health and has received awards from organizations including the Juvenile Diabetes Research Foundation, the American Diabetes Association, the American Heart Association, the March of Dimes Foundation and the French Diabetes Association. He is an elected member of the American Society for Clinical Investigation.

Ongoing research projects related to diabetes and obesity

Virtually every advance in medical science in the 20th century, from antibiotics and vaccines to drugs against common diseases and organ transplants, has been achieved through the use of animals in laboratory experiments. Our Laboratory focuses on identifying the cellular and molecular mechanisms by which estrogens and androgens influence the risks of diabetes, obesity and metabolic syndrome using rodent models. We use genetic, molecular, pharmacological and physiological tools to study mice with conditional knockouts of the estrogen or/and androgen receptors as well as rodent and human cell culture models in highly controlled environments. Students and fellows are trained to gain a full understanding of the biological processes at the root of obesity and diabetes and the ability to demonstrate that modulating sex steroid actions can have a therapeutic impact on metabolic dysfunction.

Ongoing projects include

  1. Targeted estrogen delivery using novel GLP1-estrogen fusion peptides in improving human pancreatic islet transplantation in diabetic rodent models
  2. Novel actions of the selective estrogen receptor modulator bazedoxifene in insulin sensitivity and diabetes prevention in post-menopausal mouse models
  3. Novel effects of estrogens in islet alpha-cells and preventing hyperglucagonemia.
  4. Role of the androgen receptor in pancreatic beta-cell function and insulin secretion in males. Implications for diabetes in aging
  5. Role of androgen excess in predisposing to type 2 diabetes in females via central nervous system and peripheral actions.

Lab members

Chandra Tate, MS, Medical Research Specialist and Lab manager
Camille Allard, PhD, Post-Doctoral Research Fellow
Beibei Xu, PhD, Post-Doctoral Research Fellow
Weiwei Xu, Graduate Student, BMS

Other Links

Tulane: http://tulane.edu/som/departments/medicine/endocrinology/mauvais-jarvais.cfm
ResearchGate: http://www.researchgate.net/profile/Franck_Mauvais-Jarvis/
LinkedIn: http://www.linkedin.com/in/franckmauvaisjarvisdiabetes
American Society for Clinical Investigation: http://www.the-asci.org/data/profile.php?pid=500788
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=mauvais-jarvis+f

 

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