Medical Biochemistry at Tulane University School of Medicine is divided into two first-year courses: Human Medical Cellular Biochemistry (Cellular Biochemistry, Fall semester) and Metabolic Biochemistry of Human Disease (Metabolic Biochemistry, Spring semester). These courses are designed to demonstrate the how basic principles of biochemical structure govern molecular regulation in both normal health and the disease state. The Cellular Biochemistry course focus is at the molecular and cellular level of biochemistry, providing information about how cellular structures provide function. The Metabolic Biochemistry course focuses on biochemical pathways involved in intermediary metabolism. Both courses stress normal function and why disease states occur if these functions are abrogated.Both courses consist of six blocks of lecture topics that demonstrate common and important biochemical themes and principles of cellular and metabolic function.The lectures provide case-based examples where biochemical dysfunction leads to the disease state. Learning objectives, study guides and handouts are provided for each contact hour, and all resources are provided on-line. This is supplemented with team-based learning, numerous self-assessment problem sets, and practice exams. The course utilizes traditional text and board review study resources for maximal self learning, and to help prepare students for board style examinations.The top student from both courses is designated the winner of the Adrouny Award for excellence in Medical Biochemistry.
Course Goals and Objectives
The objectives and content of the Metabolic Biochemistry of Human Disease course are designed to provide students with a comprehensive understanding of the metabolic pathways involving the four major metabolic compounds: carbohydrates, lipids, amino acids and nucleotides; and the manner by which metabolism is normally integrated and regulated. This course stresses both the normal metabolic function, and why disease states occur if normal metabolic processes are disrupted.
Students will be able to
1. Identify basic principles of structure and function of the four major metabolic compounds (carbohydrates, lipids, proteins and nucleic acids).
2. Apply the subcellular localization of metabolic pathways to coordinate metabolic regulation.
3. Differentiate the anabolic and catabolic pathways and their important enzymatic steps.
4. Estimate energy yield requirements and thermodynamic considerations.
5. Extrapolate how regulation of biochemical pathways leads to normal integrated metabolism.
6. Extrapolate how abrogation of normal integrated metabolism can result in various disease states.
David S. Franklin, Ph.D.Associate ProfessorEmail firstname.lastname@example.orgWork Phone 504-988-8868Office Location Room 6053 (Med School)Office Hours: Afternoons and by appointment
1430 Tulane Ave, New Orleans, LA 70112 504-988-5187 email@example.com