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The People of Tulane Cancer Center Research


Zakaria Abd ElmageedZakaria Abd Elmageed, Ph.D.

Research Instructor
Department of Urology
Tulane Cancer Contributing Member

Contact Information
Email: zabdelma@tulane.edu
Phone: 504-988-5539
Address: 1430 Tulane Ave., SL-42, New Orleans, LA 70112


Biographical Narrative

Dr. Abd Elmageed is a research instructor in the Department of Urology at Tulane University School of Medicine. His research interests include the cellular and molecular biology of prostate, breast and thyroid cancers. Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in the U.S. Dr. Abd Elmageed’s current research focuses on elucidating the role of signaling and tumor microenvironment on adipose-derived stem cells in prostate cancer (PCa). He is also investigating the differential expression profile of estrogen and its receptors (Alpha/Beta) in PCa based on race, age and genetic background. Tissue microarray (TMA), IHC, proteomics, microRNA arrays and other molecular techniques have been used in tissue culture, on animal models and in human samples to test this hypothesis. Dr. Abd Elmageed’s future research goal is to elucidate the role of miRNAs delivered by cancer-related exosomes in the induction of neoplastic transformation of adipose-derived stem cells into PCa. He also wants to continue to study the tumor microenvironment (niche) growth releasing factors which modulate the transformation of mesenchymal stem cells in vitro and in vivo, as this has the potential for many applications in discovering new therapeutic interventions

Selected Publications
Abd Elmageed ZY, Yang Y, Thomas R, Ranjan M, Mondal D, Moroz K, Fang Z, Rezk BM, Moparty K, Sikka SC, Sartor O, Abdel-Mageed AB. Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes. Stem Cells. 2014 Apr;32(4):983-97. doi: 10.1002/stem.1619.

Handra-Luca A, Abd Elmageed ZY, Gouhier P. CD99 Expression in nasal lobular capillary hemangioma. Histopathology. 2014 Apr 4. doi: 10.1111/his.12430. [Epub ahead of print]

Kruger S, Abd Elmageed ZY, Hawke DH, Wörner PM, Jansen DA, Abdel-Mageed AB, Alt EU, Izadpanah R. Molecular characterization of exosome-like vesicles from breast cancer cells.
BMC Cancer. 2014 Jan 27;14:44. doi: 10.1186/1471-2407-14-44.

Kim H, Abd Elmageed ZY, Ju J, Naura AS, Abdel-Mageed AB, Varughese S, Paul D, Alahari S, Catling A, Kim JG, Boulares AH. PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth. Mol Med. 2013 Aug 28;19:253-62. doi: 10.2119/molmed.2011.00001.

Abd Elmageed ZY, Moroz K, Kandil E Clinical significance of CD146 and latexin during different stages of thyroid cancer.
Mol Cell Biochem. 2013 Sep;381(1-2):95-103. doi: 10.1007/s11010-013-1691-x. Epub 2013 May 28.

Abd Elmageed ZY, Moroz K, Srivastav SK, Fang Z, Crawford BE, Moparty K, Thomas R, Abdel-Mageed AB. High circulating estrogens and selective expression of ERβ in prostate tumors of Americans: implications for racial disparity of prostate cancer. Carcinogenesis. 2013 Sep;34(9):2017-23. doi: 10.1093/carcin/bgt156. Epub 2013 May 8.

Kandil E, Tsumagari K, Ma J, Abd Elmageed ZY, Li X, Slakey D, Mondal D, Abdel-Mageed AB. Synergistic inhibition of thyroid cancer by suppressing MAPK/PI3K/AKT pathways. J Surg Res. 2013 Oct;184(2):898-906. doi: 10.1016/j.jss.2013.03.052. Epub 2013 Apr 2.

Abdel Khalek M, Abd ElMageed Z, Khan A, Broussard G, Kandil E. Cholestatic hepatitis in a patient with Graves' disease resolved with total thyroidectomy.
Trop Gastroenterol. 2011 Oct-Dec;32(4):328-30. No abstract available.

Mohammad MA, Zeeneldin AA, Abd Elmageed ZY, Khalil EH, Mahdy SM, Sharada HM, Sharawy SK, Abdel-Wahab AH. Clinical relevance of cyclooxygenase-2 and matrix metalloproteinases (MMP-2 and MT1-MMP) in human breast cancer tissue. Mol Cell Biochem. 2012 Jul;366(1-2):269-75. doi: 10.1007/s11010-012-1305-z. Epub 2012 Apr 18.

Abd Elmageed ZY, Naura AS, Errami Y, Zerfaoui M. The poly(ADP-ribose) polymerases (PARPs): new roles in intracellular transport. Cell Signal. 2012 Jan;24(1):1-8. doi: 10.1016/j.cellsig.2011.07.019. Epub 2011 Aug 5.

Abd Elmageed ZY, Gaur RL, Williams M, Abdraboh ME, Rao PN, Raj MH, Ismail FM, Ouhtit A. Characterization of coordinated immediate responses by p16INK4A and p53 pathways in UVB-irradiated human skin cells. J Invest Dermatol. 2009 Jan;129(1):175-83. doi: 10.1038/jid.2008.208. Epub 2008 Aug 21.

Raj MH, Abd Elmageed ZY, Zhou J, Gaur RL, Nguyen L, Azam GA, Braley P, Rao PN, Fathi IM, Ouhtit A. Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells. Gynecol Oncol. 2008 Sep;110(3):432-8. doi: 10.1016/j.ygyno.2008.05.001. Epub 2008 Jul 7.

Ouhtit A, Abd Elmageed ZY, Abdraboh ME, Lioe TF, Raj MH. In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver. Am J Pathol. 2007 Dec;171(6):2033-9. Epub 2007 Nov 8.

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu