The People of Tulane Cancer Center Research
Yan Dong, Ph.D.
Dr. Dong is the recipient of several awards, including the American Association of Cancer Research (AACR)-Cancer Research Foundation of America Fellowship Award in Prevention Research in 2001, the AACR Scholar in Training Award and the Department of Defense Postdoctoral Fellowship Award in 2002, the AACR-Women in Cancer Research Brigid G. Leventhal Scholar in Training Award in 2003, the Department of Defense New Investigator Award in 2004, the National Cancer Institute Howard Temin Career Development Award in 2005, as well as the Jilin Provincial Scholarship Award and the American Cancer Society Research Scholar Award in 2007.
She is a reviewer for a number of journals, including Cancer Research, the International Journal of Cancer, Molecular Carcinogenesis, Cancer, Molecular Cancer Therapeutics, Clinical Cancer Research, and Molecular Cancer Research. Dr. Dong's research interests include androgen receptor signaling in selenium chemoprevention of prostate cancer, selenium sensitization of chemotherapy or hormonal therapy in relation to breast cancer, as well as prostate and breast cancer intervention with ginsenosides, a class of steroid-like compounds in ginseng.
Li S, Zhou Y, Wang R, Zhang H, Dong Y, Ip C. Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-akt and its downstream substrates. Molecular Cancer Therapeutics, 6:1031, 2007.
Zhang H, Wu Y, Malewicz B, Lu J, Li S, Marshall JR, Ip C, Dong Y. Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid. Cancer, 107:2942, 2006.
Dong Y, Zhang H, Gao AC, Marshall JR, Ip C. Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Molecular Cancer Therapeutics, 4:1047, 2005.
Dong Y, Lee S, Zhang H, Marshall JR, Gao AC, Ip C. Prostate specific antigen (PSA) expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res, 64:19, 2004.
Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Research, 52:708, 2003.
Dong Y, Ganther HE, Stewart C, Ip C. Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays. Cancer Research, 62:708, 2002.
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