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The People of Tulane Cancer Center Research


Victoria P BelancioVictoria P Belancio, Ph.D.
Assistant Professor of Structural and Cellular Biology
Member of the Tulane Center for Aging
Tulane Cancer Center Program Member

Contact Information
Email: vperepe@tulane.edu
Phone: 504-988-4506
Address: 1430 Tulane Ave., Box SL-49, New Orleans, LA 70112-2699

Biographical Narrative
Dr. Belancio was born in Berlin, Germany. She obtained her BS and MS degrees in Cytology and Genetics from Novosibirsk State University in Novosibirsk, Russia. She studied Medical Genetics at the University of Alabama at Birmingham. She received her doctoral degree in Molecular and Cellular biology from the Department of Epidemiology at Tulane University in New Orleans. She did her postdoctoral training with Dr. Prescott Deininger at Tulane University. She has been a faculty member in the Department of Structural and Cellular Biology, Tulane School of Medicine since 2008 and is a member of the Tulane Center for Aging. Dr. Belancio’s primary research interests are focused on genetic instability and cellular responses associated with the activity of mammalian retroelements. She is studying molecular mechanisms controlling the expression of and the damage from these elements in normal and cancer cells.

Selected Publications
Wertz GW, Perepelitsa VP, Ball LA. Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3501-6.

Ball LA, Pringle CR, Flanagan B, Perepelitsa VP, Wertz GW. Phenotypic consequences of rearranging the P, M, and G genes of vesicular stomatitis virus. J Virology 1999 Jun; 73(6):4705-12.

Perepelitsa-Belancio V, Deininger P. RNA truncation by premature polyadenylation attenuates human mobile element activity. Nat Genetics 2003 Dec; 35(4):363-6. [commentaries in 'The Scientist' and 'Nature Reviews Genetics']

Astrid M. Roy-Engel, Mohamed El-Sawy, Lubna Farooq, Guy L. Odom, Victoria Perepelitsa-Belancio, Heather Bruch, Oluwatosin O. Oyeniran, and Prescott L. Deininger. Human Retroelements May Introduce Intragenic Polyadenylation Signals. Cytogenetic and Genome Research, 2005;110(1-4):365-71.

Mohammed El-Sawy, Shubha Kale, Christine Dugan, Thuc Quyen Nguyen, Victoria Perepelitsa-Belancio, Heather Bruch, Astrid M. Roy-Engel, and Prescott L. Deininger. Nickel stimulates genetic instability through L1 retrotransposition. Journal of Molecular Biology, 2005 Nov 25;354(2):246-57.

Belancio VP., Hedges DJ., Deininger P. LINE-1 RNA splicing and influences on mammalian gene expression. Nucleic Acid Research. 2006 Mar 22; 34(5):1512-1521

Jinchuan Xing, Hui Wang, Victoria P. Belancio, Richard Cordaux, Prescott Deininger and Mark A. Batzer. "Emergence of new primate genes by retrotransposon-mediated sequence transduction" Proc Natl Acad Sci USA. 2006 Nov 21;103(47):17608-13.

Belancio VP, Whelton M., Deininger P. Requirements for polyadenylation at the 3' end of LINE-1 element. Gene. 2007 Apr 1;390(1-2):98-107

Belancio VP, D. Hedges, and Deininger P. Mammalian non-LTR retrotransposons: For better or worse, in sickness and in health. Review. Genome Research 2008 Mar;18(3):343-58

Belancio VP, Roy-Engel AM., Deininger P. The impact of multiple splice sites in human L1 elements. Gene. 2008 411(1-2):38-45

Wallace NA., Belancio VP., and Deininger P. L1 mobile element expression causes multiple types of toxicity. Gene 2008 Aug 1;419(1-2):75-81

Kroutter EN, Belancio VP, Wagstaff BJ, Roy-Engel AM. The RNA polymerase dictates ORF1 requirement and timing of LINE and SINE retrotransposition. PLoS Genet. 2009 Apr

Belancio VP, Deininger PL, Roy-Engel AM. Line dancing in the human genome: transposable elements and disease. Genome Med. 2009 Oct 27;1(10):97

Belancio VP, Roy-Engel AM, Pochampally RR, Deininger P. Somatic expression of Line-1elements in human tissues. Nucleic Acids Res. 2010 Jul 1;38(12)

Belancio VP, Roy-Engel AM, Deininger PL. All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol. 2010 Aug;20(4);200-10

Wallace NA, Belancio VP, Faber Z, Deininger P. Feedback inhibition of L1 and alu retrotransposition through altered double strand break repair kinetics. Mob DNA. 2010 Oct 27;1(1);22

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu