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The People of Tulane Cancer Center Research


Sean B LeeSean B. Lee, Ph.D.
Associate Professor of Pathology and Laboratory Medicine Tulane Cancer Center Program Member in the Genetics Program

Contact Information
Email: slee30@tulane.edu
Phone: 504-988-1331
Address: 1430 Tulane Ave., SL-79, New Orleans, LA 70112


Biographical Narrative

Dr. Lee received his B.S. in biology from the State University of New York at Buffalo in 1989. He carried out his doctoral studies on characterizing interferon-induced double-stranded RNA activated kinase (PKR) with Dr. Mariano Esteban at the State University of New York, Health Science Center at Brooklyn, obtaining his Ph.D. in 1994. He then joined the laboratory of Dr. Daniel Haber at the Massachusetts General Hospital Cancer Center in Boston to carry out his postdoctoral studies on dissecting the functions of Wilms Tumor Suppressor gene, WT1, and EWS-WT1, an oncogene created by a chromosomal translocation in Desmoplastic Small Round Cell Tumor (DSRCT). Dr. Lee joined the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH as a tenure-track investigator in 2001. In 2012, he joined the Tulane University School of Medicine as an associate professor in the Department of Pathology & Laboratory Medicine. Dr. Lee serves as an academic editor for PLOS ONE, as well as an associate editorial board member for the American Journal of Cancer Research.


Selected Publications
Park, J.H., Kang, H.J., Kang, S.I., Lee, J.E., Hur, J., Ge, K., Mueller, E., Li, H., Lee, B.C. and Lee, S.B. (2013). A multifunctional protein EWS is essential for early brown fat lineage determination. Developmental Cell 26:393-404.

Kook, S.H., Cho, J., Lee, S.B. and Lee, B.C. (2013). A nucleotide sugar, UDP-Glucose, is a novel mobilizer of long-term repopulating primitive hematopoietic cells. J. Clinical Investigation 123:3420-3435.

Cho, J., Shen, H., Yu, H., Li, H., Cheng, T., Lee, S.B. and Lee, B.C. (2011). Ewing's sarcoma gene EWS regulates hematopoietic stem cell senescence. Blood 117:1156-1166.

Park, J., Kang, S.I., Lee, S.Y., Zhang, X.F., Kim, M.S., Beers, L.F., Lim, D.S. Avruch, J., Kim, H.S. and Lee, S. B. (2010). Tumor Suppressor Ras-Association Domain Family 5 (RASSF5/NORE1) Mediates TNF-alpha Induced Apoptosis. J. Biol. Chem. 285:35029-35038.

Kim, M.S., Yoon, S.K., Bollig, F., Kitagaki, J., Hur, W.H., Whye, N., Wu, Y.P., Rivera, M.G., Park, J.Y., Kim, H.S., Malik, K., Bell, D., Englert, C., Perantoni, A.O., and Lee, S.B. (2010). A Novel Wilms Tumor 1 (WT1) Target Gene Negatively Regulates the WNT Signaling Pathway. J. Biol. Chem. 285:14585-14593.

Sohn, E.J., Li, H., Reidy, K., Beers, L.F., Christensen, B.L. and Lee, S. B. (2010). EWS/FLI1 Oncogene Activates Caspase 3 Transcription and Triggers Apoptosis In Vivo. Cancer Research 70:1154-1163

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Li, H., Smolen, G.A., Beers, L.F., Xia, L., Gerald, W., Wang, J., Haber, D.A., and Lee, S.B. (2008). Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in Desmoplastic Small Round Cell Tumor. PLoS ONE 3(6):e2353.

Li, H., Watford, W., Li, C., Parmelee, A., Bryant, M.A., Deng, C., O'shea, J., and Lee, S.B. (2007). Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J. Clinical Investigation 117:1314-1323.

Kim, H.S., Kim, M.S., Hancock, A.L., Harper, J.C., Park, J.Y., Poy, G., Perantoni, A.O., Cam, M., Malik, K., and Lee, S.B. (2007). Identification of novel WT1 target genes implicated in kidney development. J Biol. Chem. 282:16278-16287.

Kim, H.S., Li, H., Cevher, M., Parmelee, A., Fonseca, D., Kleiman, F.E., and Lee, S.B. (2006). DNA damage-induced BARD1 phosphorylation is critical for the inhibition of pre-mRNA processing by BRCA1/BARD1 complex. Cancer Research 66:4561-4565.

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu