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The People of Tulane Cancer Center Research


Samuel J LandrySamuel J Landry, Ph.D.
Professor of Biochemistry
Member, Tulane/Xavier Center for Bioenvironmental Research
Tulane Cancer Center Contributing Member

Contact Information
Email: landry@tulane.edu
Phone: 504-988-3990
Address: 1430 Tulane Ave., Box SL-43, New Orleans, LA 70112-2699

Biographical Narrative
Dr. Landry received his B.S. in zoology from Louisiana State University (LSU), Baton Rouge in 1982 and then carried out doctoral studies with Dr. Sue Bartlett at LSU on protein import into chloroplasts, receiving his Ph.D. in 1988. He carried out postdoctoral studies with Dr. Lila Gierasch at Southwestern Medical Center, Dallas, working on the structure and function of heat shock proteins and joined the Tulane faculty in 1993. He has published over forty papers on heat shock protein structure-function and antigen structure-immunology, and he has served on numerous NSF and NIH review panels.

His work employs biochemical and biophysical techniques, including nuclear magnetic resonance (NMR) spectroscopy to investigate structure/function relationships in protein-protein interactions, especially those involved in cellular stress and immune responses. Molecular chaperones are implicated in a variety of cellular processes, including DNA replication, gene expression, and protein translocation across membranes, in addition to the heat shock response. The goal of this research is to understand at a physical chemical level how Escherichia coli molecular chaperones cooperate in the management of protein-protein interactions. Dr. Landry's research has included study of the structural instability and T-cell epitope immunodominance. Humoral and cellular immunity to HIV and other pathogens depend on antigen-specific CD4+ T cell responses directed against peptides presented in MHC class II antigen presenting proteins. Generally, CD4+ T-cell responses are focused on only a few immunodominant regions of naturally processed antigens. We have found that immunodominant regions occur in the sequences flanking locally unstable segments of an antigen's three-dimensional structure, and we are now modifying CD4+ helper T-cell immune responses to recombinant antigens by engineering their processing and presentation.

Selected Publications
Landry SJ, Three-dimensional structure determines the pattern of CD4+ T-cell epitope dominance in influenza hemagglutinin, Journal of Virology 2007; 82:1238-1248.

Mirano-Bascos D, Tary-Lehmann M and Landry SJ, Antigen structure influences helper T-cell epitope dominance in the human immune response to HIV envelope glycoprotein gp120, European Journal of Immunology 2008; 38:1-7.

Melton SJ and Landry SJ, Three dimensional structure directs T-cell epitope dominance associated with allergy, Clinical and Molecular Allergy, 2008; 6:9.

Li H, Xu C-F, Blais S, Wan Q, Zhang H-T, Kong X, Landry SJ and Hioe CE, Proximal glycans outside of the epitopes regulate the presentation of HIV-1 envelope gp120 helper epitopes, Journal of Immunology, 2009; 182:6369-6378.

Mirano-Bascos D, Steede NK, Robinson JE and Landry SJ, Influence of disulfide-stabilized structure on the specificity of helper T-cell and antibody responses to HIV envelope glycoprotein gp120, Journal of Virology 2010; 84:3303-3311.

Curiel TJ, Morris C, Brumlik M, Landry SJ, Finstad K, Nelson A, Joshi V, Hawkins C, Alarez X, Lackner A, Mohamadzadeh M, Peptides identified through phage display direct immunogenic antigen to dendritic cells, The Journal of Immunology 2004;172:7425-7431.

Shewmaker F, Kerner MJ, Hayer-Hartl M, Klein G, Georgopoulos C, Landry SJ, A mobile loop order-disorder transition modulates the speed of chaperonin cycling, Protein Science 2004;13:2139-2148.

Carmicle S, Steede NK and Landry SJ, Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopes, Molecular Immunology 2006; 44:1159-1168.

Horne BE, Li T, Genevaux P, Georgopoulos C and Landry SJ, The hsp40 J-domain stimulates hsp70 when tethered by the client to the ATPase domain, Journal of Biological Chemistry, accepted for publication.

 

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu