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The People of Tulane Cancer Center Research


Nick MakridakisNick Makridakis, PhD
Assistant Professor of Epidemiology
Tulane Cancer Center Program Member

Contact Information
Email: nmakrida@tulane.edu
Phone: 504-988-5418
Address: 1430 Tulane Ave., SL-68, New Orleans, LA 70112-2699


Biographical Narrative

Nick Makridakis was born in Athens, Greece. He obtained his B.S. in biology at the University of Athens in 1989. He then moved to the United States and obtained his Ph.D. in biochemistry and molecular biology at the University of Southern California (USC) in Los Angeles, 1997. Dr. Makridakis conducted his postdoctoral studies at the Institute of Genetic Medicine at the USC, 1997-2001, under the mentorship of Juergen Reichardt, Ph.D., and was an American Cancer Society Research Fellow from 1998-2000. He became an assistant professor of research in 2002 in the Department of Biochemistry and Molecular Biology at USC. Makridakis moved to New Orleans in 2007 to accept his current position in the Department of Epidemiology. He is interested in understanding the complex cooperative relationship between genetic and environmental contributors of multi-factorial diseases, particularly cancer.

Selected Publications
Makridakis NM, Phipps T, Srivastav S, Reichardt JK. PCR-free method detects high frequency of genomic instability in prostate cancer. Nucleic Acids Res. 2009 Dec;37(22):7441-6

Makridakis NM, Caldas Ferraz LF, Reichardt JK. Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif. Hum Mutatl 2009 Jan;30(1);39-48.

Pearce CL, Van Den Berg DJ, Makridakis N, Reichardt JK, Ross RK, Pike MC, Kolonel LN, Henderson BE. Hum Mol Genet. 2008 Aug 15;17(16):2456-61.

Makridakis NM, Reichardt JKV. Pharmacogenetic analysis of human steroid 5alpha reductase type II: comparison of finasteride and dutasteride. J Mol Endocrinol, 34: 617-623, 2005.

Makridakis NM, Akalu A, Reichardt JKV. Identification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue. Oncogene, 23: 7399-7405, 2004.

Makridakis NM, Buchanan G, Tilley W, Reichardt JKV. Androgen metabolic genes in prostate cancer predisposition and progression. Front Biosci, 10: 2892-2903, 2005

Makridakis NM, Reichardt JKV. MAPA: multiplex automated primer extension analysis: simultaneous genotyping of up to four polymorphisms. BioTechniques, 31: 1374 - 1380, 2001.

Makridakis NM, diSalle E, Reichardt JKV. Biochemical and pharmacogenetic dissection of human steroid 5alpha-reductase type II. Pharmacogenet, 10: 407-413, 2000.

Makridakis NM, Ross RK, Pike MC, Crocitto LE, Kolonel LN, Pearce CL, Henderson BE, Reichardt JKV. Association of missense substitution in the SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles USA. The Lancet, 354: 975-978, 1999.

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu