Joseph A. Lasky, M.D.
Associate Professor of Medicine Section of Pulmonary Diseases
Co-Director of Interstitial Lung Disease Clinic
Tulane Cancer Center Program Member
Address: 1430 Tulane Ave., Box SL-9, New Orleans, LA 70112-2699
Dr. Lasky received his M.D. in 1985 from the University of Minnesota and completed his medical residency in 1988 at the Mayo Graduate School of Medicine, Rochester. He completed a fellowship in 1992 at Duke University Medical Center, Durham, NC. The primary focus of Dr. Lasky's research is the pathobiology of pulmonary fibrosis. Presently he is evaluating the role of peptide growth factors (platelet-derived growth factor (PDGF) and connective tissue growth factor (CTGF)) in the pathogenesis of lung fibrosis. Current experiments involve the use of transgenic mice that overexpress PDGF and CTGF in a lung specific manner, and mice with inducible dominant-negative receptor mutants and inducible ribozymes. Dr. Lasky's laboratory also currently is conducting clinical studies of isocyanate and other workplace asthmas. The overall goal of the project is to collaborate with the NIOSH Division of Respiratory Disease Studies (RDS) in examining workers suspected of having occupational asthma induced by exposure to isocyanates. A major focus of the project will be the oriented strand wood board industry. The specific aims of the project are to confirm objectively the diagnosis of specific asthma induced by low molecular weight haptens, especially isocyanates, in workers through clinical challenge tests. Additionally, Dr. Lasky is researching the pathobiology of pulmonary hypertension as related to the inhibition of PDGF signal transduction. This proposal investigates the role of PDGF signal transduction in the pathogenesis of pulmonary vascular hypertension induced by hypobaric hypoxemia. The specific aim employs selective tyrosine kinase inhibitors and chimeric mice.
Lasky JA, Bonner JC, Tonthat B, Brody AR. Chrysotile asbestos induces PDGF-A chain-dependent proliferation in human and rat lung fibroblasts in vitro. Chest 109: 26S-28S (1996)
Lasky JA, Brody AR. Interleukins Involved In The Pathogenesis Of Chronic Airway Inflammation. Res Immunol 148: 39-47 (1997)
Lasky JA, Liu J-Y, Tonthat B, Friedman M, Brody AR. Upregulation of the PDGF-alpha-receptor precedes the development of asbestos-induced lung fibrosis in rats. Am J Respir Crit Care Med 157: 1652-1657 (1998)
Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, Athas G, Lungarella G, Brody AR, Friedman M. Connective tissue growth factor (CTGF) expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol 275: L365-L371 (1998)
Lasky JA, Brody AR. Pathogenesis of Interstitital Pulmonary Fibrosis Mediated by Peptide Growth Factors. Environmental Health Perspectives 108: 751-762 (2000)
Lasky JA, Ortiz LA. Antifibrotic therapy for the treatment of pulmonary fibrosis. American Journal of Medical Sciences (in press).