John A. McLachlan, Ph.D.
Professor of Environmental Studies
Director, Tulane/Xavier Center for BioEnvironmental Research
Tulane Cancer Center Program Member
Address: 1430 Tulane Ave., SL-3, New Orleans, LA 70112-2699
Dr. McLachlan received his B.A. degree in Liberal Arts from the Johns Hopkins University and a doctoral degree in pharmacology from the George Washington University. Before coming to Tulane and Xavier in 1995, he spent the previous two decades at the National Institute of Environmental Health Sciences (NIEHS). While at NIEHS, Dr. McLachlan's scientific contributions led to his discovery of the mechanisms by which environmental chemicals alter fetal development. Dr. McLachlan was named Scientific Director of the NIEHS in 1989. In his first five years in New Orleans Dr. McLachlan established a program on the Environment and Women's Health, formed the nation's first Center in Environmental Astrobiology and initiated the Mississippi River Interdisciplinary Research Program. Dr. McLachlan's scientific findings have been published in over 150 journal articles, 50 book chapters and 5 edited books. He presents, on average, 30 invited lectures per year and has provided scientific counsel to numerous government agencies, most recently the European Parliament. Dr. McLachlan's Environmental Endocrinology Laboratory studies environmental signaling. The major area of concentration for the lab's work is on environmental estrogens, both natural and synthetic chemicals that interact with the estrogen receptor. Lab members examine the interaction of environmental chemicals with other steroid receptors, as well as cellular signaling pathways. Model systems used in these studies include breast and endometrial cancer cell lines. The function of these compounds in animal systems is also examined.
Burow ME, Weldon CB, Melnik LI, Duong B, Collins-Burow BM, Klippel A, Beckman BS, McLachlan JA. (2000) Phosphatidylinositol-3 Kinase/Akt Mediated Regulation of MF-B Signaling Events as a Mechanism for Suppression of TNF-induced Apoptosis. Biochem Biophys Res Comm 271(2): 342-345.
Burow ME, Weldon CB, Chiang T-C, Tang Y, Collins-Burow BM, Rolfe K, Li S, McLachlan JA, Beckman BS. (2000) Differences in Protein Kinase C and Estrogen Receptor, Expression and Signaling Correlate with Apoptotic Sensitivity of MCF-7 Breast Cancer Cell Variants. Int J Oncol 16: 1179-1187.
Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J, McLachlan JA. (2000) Proliferative Lesions and Reproductive Tract Tumors in Male Descendants of Mice Exposed Developmentally to Diethylstilbestrol. Carcinogenesis 21(7): 1355-1363.
Li S, Chiang T-C, Davis GR, Williams RM, Wilson VP, McLachlan JA. (2001) Decreased expression of Wnt-7a mRNA is inversely associated with the expression of estrogen receptor a in human uterine leiomyoma. J Clin Endocrinol Metab 86(1): 454-457.
Burow ME, Boue S, Collins-Burow BM, Melnik LI, Duong BN, Li S, Wiese TE, Cleavland E, McLachlan JA. (2001) Phytochemical Glyceollins, Isolated from Soy, Mediate Anti-hormonal Effects through Estrogen Receptor a and b. J Clin Endocrinol Metab 86(4): 1750-1758.
Collins-Burow BM, Burow ME, Duong BN, McLachlan JA. (2001) The Estrogenic and Anti-estrogenic Activities of Flavonoid Phytochemicals Through Estrogen Receptor Binding Dependent and Independent Mechanisms. Nutrition and Cancer (in press).