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The People of Tulane Cancer Center Research


Jeffrey HanJeffrey S. Han, M.D., Ph.D.
Assistant Professor of Biochemistry and Molecular Biology
Tulane Cancer Center Program Member in the Genetics Program

Contact Information
Email: jhan5@tulane.edu
Phone: 504-988-5920
Address: 1430 Tulane Ave., SL-43
New Orleans, LA 70112

Biographical Narrative
Dr. Han received his B.A and B.S. in biochemistry and economics from the University of Pennsylvania. He completed his M.D. and Ph.D. at the Johns Hopkins University School of Medicine, performing his graduate work in the laboratory of Jef Boeke. After graduation, he started his laboratory as a staff associate at the Carnegie Institution of Washington, Department of Embryology, on the Johns Hopkins campus. He moved to Tulane University as an assistant professor in the Department of Biochemistry and Molecular Biology in 2013. Dr. Han’s main research interests are the molecular and cell biology of transposition, and the contribution of transposition to human health and disease.

Selected Publications
Horn, A.V. Klawitter, S., Held, U., Berger, A., Jaguva Vasudevan, A.A., Bock, A., Hofmann, H., Hanschmann, K.M., Trosemeier, J.H., Flory, E., Jabulowsky, R.A., Han, J.S., Lower, J., Lower, R., Munk, C., and Schumann, G.G. Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity. Nucleic Acids Research (2013) doi:10.1093/nar/gkt898

Han, J.S., and Shao, S. Circular retrotransposition products generated by a LINE retrotransposon. Nucleic Acids Research (2012) 40:10866. *Chosen as a Featured Article

An, W., Dai, L., Niewiadomska, A.M., Yetil, A., O’Donnell, K.A., Han, J.S., and Boeke, J.D. Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs. Mob DNA (2011) 2:2.

Han, J.S. Non-long terminal repeat (non-LTR) retrotransposons: mechanisms, recent developments, and unanswered questions. Mob DNA (2010) 1:15.

Dong, C, Poulter, R.T., Han, J.S. LINE-like Retrotransposition in Saccharomyces cerevisiae. Genetics (2009) 181, 301-311. *Chosen for Issue Highlights

An, W., Han, J.S., Schrum, C.M., Maitra, A., Koentgen, F., and Boeke, J.D. Controlled activation of a single-copy L1 transgene in mice by Cre recombinase. Genesis (2008) 46, 373-383.

Boeke, J.D., An, W., Dai, L., Davis, E.S., Han, J.S., O’Donnell, K.A., Scheifele, L.Z., and Wheelan, S.J. Retrotransposons – natural and synthetic. In Retrotransposition, Diversity and the Brain (eds. Gage, F.H. & Christen, Y.) 21-32 (Springer-Verlag Berlin Heidelberg, 2007).

An, W., Han, J.S., Wheelan, S.J., Davis, E.S., Coombes, C.E., Ye, P., Triplett, C., and Boeke, J.D. Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci USA (2006) 103:18662-18667.

Wheelan, S.J., Aizawa, Y., Han, J.S., and Boeke, J.D. Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution. Genome Research (2005) 15, 1073-1078.

Han, J.S., and Boeke, J.D. LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression? Bioessays (2005) 27, 775-784.

Han, J.S., and Boeke, J.D. A highly active synthetic mammalian retrotransposon. Nature (2004) 20, 314-318. *Chosen for News and Views - Nature (2004) 20, 253-255.

Han, J.S., Szak, S.T., and Boeke, J.D. Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature (2004) 20, 268-274. *Chosen for News and Views - Nature (2004) 20, 253-255.

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu