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The People of Tulane Cancer Center Research


Haitao ZhangHaitao Zhang, Ph.D.
Associate Professor, Department of Pathology & Laboratory Medicine
Tulane Cancer Center Program Member

Contact Information
Email: hzhang@tulane.edu
Phone: 504-988-7696
1430 Tulane Ave, SL-79, New Orleans, LA 70112-2699


Biographical Information

Dr. Zhang received his B.S. in molecular biology from the Nankai University, Tianjin, China, in 1992. He completed his doctoral training in the Department of Experimental Pathology at Roswell Park Cancer Institute, receiving his Ph.D. in 2000. Subsequently, he conducted postdoctoral research under the mentorship of Dr. Margot Ip, studying the mechanism of TNF alpha suppression of functional differentiation of mammary epithelial cells. From 2001 to 2003, Dr. Zhang worked at the Microarray and Genomics Core Facility at Roswell Park as a bioinformatics specialist. He was recruited to the Department of Cancer Chemoprevention at Roswell Park in 2003 as a research scientist and was promoted to research assistant professor in 2005. In 2008, he joined the faculty of Tulane University School of Medicine as a tenure-track assistant professor in the Department of Pathology and Laboratory Medicine, and was promoted to associate professor with tenure in 2014. Dr. Zhang’s research centers on targeting the androgen receptor signaling axis for the prevention and treatment of prostate cancer. He has severed on several DOD and NIH grant review panels.

Recent Publications
Haitao Zhang, Yang Zhan, Xichun Liu, Yanfeng Qi, Guanyi Zhang, Oliver Sartor, and Yan Dong. (2013). Splicing variants of androgen receptor in prostate cancer. Am J Clin Exp Urol 2013;1(1):18-24. Epub December 25, 2013

Zhan Y, Cao B, Qi Y, Liu S, Zhang Q, Zhou W, Xu D, Lu H, Sartor O, Kong W, Zhang H, and Dong Y. Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer. Int J Cancer. 2013 Apr 11. doi: 10.1002/ijc.28202.

Bo Cao, Jingkai Gu, Zhenggang Xiong, Xichun Liu, Jing Li, Thomas Wiese, Xueqi Fu, Helen Cheng, Paul S. Rennie, Oliver Sartor, Benjamin R. Lee, Lijuan Zhao, Haitao Zhang, and Yan Dong. (2012). 20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor. International Journal of Cancer, Mar 15;132(6):1277-87.

Wu Y, Chhipa RR, Zhang H, Ip C. (2011). The antiandrogenic effect of finasteride against a mutant androgen receptor. Cancer Biol Ther. 2011 May 15;11(10):902-9.

Jing Li, Bo Cao, Xichun Liu, Xueqi Fu, Li Chen, Zhenggang Xiong, Oliver Sartor, Yan Dong, and Haitao Zhang. (2011). Berberine suppresses androgen receptor signaling in prostate cancer. Molecular Cancer Therapeutics, 10(8):1346-56. PMID:21613449.

Haitao Zhang, Jian Fang, Dian Yao, Yue Wu, Clement Ip, Yan Dong. (2010) Activation of FOXO1 is critical for the anticancer effect of methylseleninic acid in prostate cancer cells. The Prostate, 70(12):1265-73.

Xichun Liu, Ruijuan Gao, Yan Dong, Lifang Gao, Yanying Zhao, Lijuan Zhao, Xuejian Zhao, and Haitao Zhang. (2010) Survivin gene silencing sensitizes prostate cancer cells to the anticancer effect of selenium. BMC Cancer 2010, 10:418.

Shuang Liu, Yanfeng Qi, Yubin Ge, Tamika Duplessis, Brian G. Rowan, Clement Ip, Helen Cheng, Paul S. Rennie, Izumi Horikawa, Arthur J. Lustig, Qun Yu, Haitao Zhang, and Yan Dong. (2010) Telomerase as an important target of androgen-signaling blockade for prostate cancer treatment. Molecular Cancer Therapeutics 9: 2016-2025.

Haitao Zhang, Yue Wu, Barbara Malewicz, Junxuan Lu, Song Li, James Marshall, Clement Ip, and Yan Dong. (2006) Augmented Suppression of Androgen Receptor Signaling by a Combination of α-Tocopheryl Succinate and Methylseleninic Acid. Cancer, 107(12): 2942-2948

Yan Dong, Haitao Zhang, Allen C. Gao, James R. Marshall, and Clement Ip. (2005) Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Molecular Cancer Therapeutics 4(7):1047-1055.

Haitao Zhang, Yan Dong, Hongjuan Zhao, James D. Brooks, Lesleyann Hawthorn, Norma Nowak, James R. Marshall, Allen C. Gao, and Clement Ip. (2005) Microarray data mining for potential selenium targets in chemoprevention of prostate cancer. Cancer Genomics and Proteomics, 2:97-114.

Haitao Zhang, Haiwei Zhang, Laura Lee, and Margot M. Ip (2004). The LIP isoform of C/EBPß, but not NFκB, mediates the transcriptional inhibition of ß-casein by tumor necrosis factor-α (TNF). Endocrinology, 145:2833-2844.

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5187 medsch@tulane.edu