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The People of Tulane Cancer Center Research


Erik K FlemingtonErik K. Flemington, Ph.D.
Professor of Pathology
Zimmerman Professor of Cancer Research
Program Director, Cancer Genetics
Director, Cancer Crusaders Bioinformatics Core
Tulane Cancer Center Program Member



Contact Information

Email: eflemin@tulane.edu
Phone: 504-988-1167
Address: 1430 Tulane Ave., Box SL-79, New Orleans, LA 70112-2699


Biographical Narrative

Dr. Flemington received his B.S. degree in Chemical Engineering from Michigan Technological University. He carried out his doctoral studies in Dr. Prescott Deininger's laboratory and received a Ph.D. in Biochemistry and Molecular Biology from the Louisiana State University in New Orleans in 1987. His post-doctoral work was carried out in Dr. Sam Speck's laboratory at the Dana Farber Cancer Institute in Boston where he investigated the transcriptional mechanisms involved in the Epstein Barr virus (EBV) reactivation switch. In 1991, Dr. Flemington was appointed as an Instructor of Pathology at Harvard University and in 1995, he was appointed as Assistant Professor in the department of Medicine at Harvard Medical School. In 2000, he joined the Tulane Cancer Center as an Associate Professor in the department of Pathology.

Selected Publications
O’Grady, T, Cao, S, Strong, MJ, Concha, M, Wang, X, Splinter BonDurant, S, Adams, M, Baddoo, M, Srivastav, SK, Lin, Z, Fewell, C, Yin, Q, and Flemington, EK. Global bidirectional transcription of the Epstein-Barr virus genome during reactivation. J Virol. 2013; Nov 20 [Epub ahead of print] PMID: 24257595

Strong, MJ, O’Grady, T, Lin, Z, Xu, G, Baddoo, M, Parsons, C, Zhang, K, Taylor, CM, and Flemington, EK. Epstein-Barr Virus and Human Herpesvirus 6 Detection in a non-Hodgkin’s Diffuse Large B-Cell Lymphoma Cohort using RNA-Seq. J Virol. 2013; 87:13059-13062. PMID: 24049168

Strong, MJ, Xu, G, Coco, J, Baribault, C, Vinay, DS, Lacey, MR, Strong, AL, Lehman, TA, Seddon, MB, Lin, Z, Concha, M, Baddoo, M, Ferris, MB, Swan, KF, Sullivan, DE, Burow, ME, Taylor, CM and Flemington, EK. Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity; implications for possible immune adjuvant therapy. PLOS Pathogens 2013; 9: e1003341. PMID: 23671415

Lin, Z, Wang, X, Strong, MJ, Concha, M, Baddoo, M, Xu, G, Baribault, C, Fewell, C, Hulme, W, Hedges, D, Taylor, CM, Flemington, EK. Whole genome sequencing of the Akata and Mutu Epstein-Barr virus strains. J Virol. 2013; 87:1172-1182 PMID: 23152513.

Lin, Z, Puetter A, Coco J, Xu G, Strong, MJ, Wang, X, Fewell, C, Baddoo, M, Taylor CM, Flemington, EK. Detection of Murine Leukemia Virus in the Epstein-Barr Virus-Positive Human B-Cell Line JY, Using a Computational RNA-Seq-Based Exogenous Agent Detection Pipeline, PARSES. J Virol. 2012 Mar;86(6):2970-7. PMID:22238296.

Concha, M, Wang, X, Cao, S, Baddoo, M, Fewell, C, Lin, Z, Hulme, W, Hedges, D, McBride, J, Flemington, EK. Identification of new viral genes and transcript isoforms during Epstein-Barr virus reactivation using RNA-seq. J Virol. 2012 86:1458 (PMID: 22090128).

Lin, Z, and Flemington, EK. miRNAs in the pathogenesis of oncogenic human viruses. Cancer Letters, 2011; 305: 186-199 (PMID: 20943311)

Deng, N, Puetter, A, Zhang, K, Johnson, K Zhao, Z Taylor, CM, *Flemington, EK, *Zhu, D. Isoform-level microRNA-155 target prediction using RNA-seq. Nucl. Acids Res. 2011; 39:e61 (PMID: 21317189) (*corresponding authors)

 Xu, G, Deng, N, Zhao, Z, Zhang, K, Judeh, T, Flemington, EK, Zhu, D. SAMMate: a GUI tool for processing short read alignments in SAM/BAM format. Source Code for Biology and Medicine. 2011; 6:2 (PMID: 21232146)

Lin, Z, Wang, X, Fewell, C, Cameron, J, Yin, Q, Flemington, EK. Differential expression of the miR-200 family microRNAs in epithelial and B-cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member, miR-429.  J. Virol. 2010; 84:7892-7897 (PMID: 20484493).

Lin Z, Xu G, Deng N, Taylor C, Zhu D, Flemington EK. Quantitative and qualitative RNA-Seq-based evaluation of Epstein-Barr virus transcription in type 1 latency Burkitt's lymphoma cells. J. Virol. 2010 Dec;84 (24);13053-8

Lin Z, Flemington EK. miRNAs in the pathogenesis of oncogenic human viruses. Cancer Lett. 2010 Oct 11

Xu G, Fewell C, Taylor C, Deng N, Hedges D, Wang X, Zhang K, Lacey M, Zhang H, Yin Q, Cameron J, Lin Z, Zhu D, Flemington EK. Transciptome and targetome analysis in MIR155 expressing cells using RNA-seq. RNA 2010 Aug; 16(8):1610-22.

Lin Z, Wang X, Fewell C, Cameron J, Yin Q, Flemington EK. Differential expression of the miR-200 family microRNAs in epithelial and B cells and regulation of Epstein-Barr virus reactivation by the miR-200 family member miR-429. J. Virol. 2010 Aug;84(15):7892-7.

Yin Q, Wang X, Fewell C, Cameron J, Zhu H, Baddoo M, Lin Z, Flemington EK. MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation. J. Virol. 2010 Jul;84(13):6318-27

Cameron JE, Fewell C, YinQ, McBride J, Wang X, LinA, Flemington EK. Epstein-Barr virus growth/latency lll program alters cellular microRNA expression. Virology. 2008 Dec 20;382(2):257-66.

Yin Q, McBride J, Fewell C, Lacey M, Qang X, Lin Z, Cameron J, Flemington EK. MicroRNA-155 is an Epstein-Barr virus-induced gene that modulates Epstein-Barr virus-regulated gene expression pathways.  J. Virol. 2008 Jun;82(11):5295-306.

Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways.  J. Virol. 2008 Feb;82(4):1946-58.

 

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