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The People of Tulane Cancer Center Research


Debasis MondalDebasis Mondal, Ph.D.
Associate Professor of Pharmacology
Tulane Cancer Center Program Member

Contact Information
Email: dmondal@tulane.edu
Phone: 504-988-4668
Address: 1430 Tulane Ave., Box SL-83, New Orleans, LA 70112-2699


Biographical Narrative

Dr. Mondal obtained his Ph.D. from the Department of Microbiology and Immunology at Louisiana State University Medical Center (LSUMC) under the guidance of Dr. Luftig. His thesis research was on ‘The regulation of HIV-1 LTR-directed gene expression via the transactivator (Tat) protein’. During these investigations, he gained experience in molecular biology, cloning and HIV infectivity protocols. In 1996, he joined Dr. Krishna C. Agrawal’s laboratory in the Department of Pharmacology at Tulane University Medical Center (TUMC) in New Orleans, LA, as a postdoctoral fellow. In 2003, he was promoted to assistant professor in the Department of Pharmacology. Dr. Mondal’s current research interest is focused on developing novel strategies to increase the efficacies of chemotherapeutic drugs by using a combination of pharmacological and gene therapy approaches. Despite the availability of potent chemotherapeutics, the induction of multidrug resistance (MDR) is a formidable challenge to drug pharmacokinetics in vivo. Two approaches are being investigated to target and chemosensitize prostate cancer cells in sequestered bone-tumor foci. The first project focuses on tumor site-specific delivery of the prodrug ganciclovir. His laboratory has evidence that tumor-tropic mesenchymal stem cells (MSCs) can be genetically engineered to activate the anticancer effects of ganciclovir. Secondly, his team is investigating the role of oxidative stress and Nrf2, a transcription factor that regulates ROS signaling, in aggressive prostate tumors. They envision that by altering Nrf2-mediated signaling pathways, they can both suppress tumor growth and enhance chemosensization in prostate cancer cells.

Recent Publications
D. Mondal
, L. Pradhan, and V. F. LaRussa,. (2004). Signal transduction pathways involved in Lineage-specific differentiation of NSCs: Can the knowledge gained from blood be used in the brain? (Review). Cancer Invest. 22(6):925-943.

D. Mondal, C.A. Williams, M. Ali, M. Eilers, and Krishna C. Agrawal. (2005). The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp Biol Med.;230(9):631-44

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Reiser J, Zhang XY, Hemenway CS, Mondal D, Pradhan L, La Russa VF. (2005) Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases. (Review). Expert Opin Biol Ther.;5(12):1571-84.

Kukreja P, Abdel-Mageed AB, Mondal D, Liu K, Agrawal KC.(2005). Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha (CXCL12) increases endothelial adhesion and transendothelial migration: role of MEK/ERK signaling pathway-dependent NF-kappaB activation. Cancer Res.;65(21):9891- 9898.

M. Eilers, U. Roy, and D. Mondal. (2008). MRP (ABCC) transporters predominantly efflux anti-HIV agents, Saquinavir and Zidovudine, from human brain endothelial cells. Exp Biol Med.;233(9):1149-60. (Selected as a Feature Article and Press Release).

G. Chakravarty, A.A. Santillan, C. Galer, H.P. Adams, A.K. El-Naggar, S.A. Jasser, S. Mohsin, D. Mondal, G. L. Clayman, and J.N. Myers. (2009). Phosphorylated insulin like growth factor-I receptor expression and its clinico-pathological significance in histologic subtypes of human thyroid canceer. Exp Biol Med. [Epub ahead of print].

U. Roy, G. Chakravarty, K. Bentrup, and D. Mondal. (2009). Montelukast is a potent and durable inhibitor of MRP2-mediated efflux of taxol and saquinavir. Biol Pharm Bull. 32(12):2002-2009.

P.S. Koka, D. Mondal, M. Schultz, A.B. Abdel-Mageed and K.C. Agrawal. (2010). Studies on Molecular Mechanisms of Growth Inhibitory Effects of Thymoquinone against Prostate Cancer Cells: Role of Reactive Oxygen Species. Exp Biol & Med (In Press).

Samantha L. Gerlach, Ulf Göransson, Geetika Chakravarty, Ramesh Rathinakumar, William C. Wimley, Steven P. Darwin and Debasis Mondal. (2010). Anticancer and Chemosensitizing Abilities of Cycloviolacin O2 From Viola odorata and Psyle cyclotides From Psychotria leptothyrsa. Biopolymers: Peptide Science. (In Press).

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5187 medsch@tulane.edu