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The People of Tulane Cancer Center Research


Chang HanChang Han, M.D., Ph.D.
Associate Professor, Department of Pathology and Laboratory Medicine
Tulane Cancer Center Program Member

Contact Information
Email: chan@tulane.edu
Phone: 504-988-5224
Address: 1430 Tulane Ave., SL-79, New Orleans, LA 70112


Biographical Narrative

Dr. Han received her MD from Harbin Medical University, China. She carried out doctoral studies on the detection of human T-cell leukemia virus type-1 in a human T-lyphoblastic lymphoma xenotransplant in nude mouse and an exploration of the mechanism of horizontal oncogenesis in the xenograft, obtaining her Ph.D. She then carried out postdoctoral studies on gene targeting at the Institute of Genetics, Chinese Academy of Sciences, followed by research on the regulation of cytosolic phospholipase A2alpha (cPLA2alpha) and cyclooxygenase-2 (COX-2)-derived prostaglandin and related signaling pathways in liver cancer at the Department of Pathology of University of Pittsburgh School of Medicine. She generated two novel transgenic mice with targeted expression of the cPLA2alpha and COX-2, respectively, in the liver and gained significant expertise in a variety of in vitro and iv vivo model systems for the study of liver cell biology and cancer. In 2005 she was promoted as an assistant professor of pathology. Since relocating to Tulane University in December 2009, she took an Associate Professor position in Pathology and Laboratory Medicine at School of Medicine where she continues her active research in hepatic carcinogenesis.

Selected Publications
Han C, Bowen WC, Li GY, et al. Cytosolic Phospholipase A2alpha and PPAR-gamma Signaling Pathway Counteracts TGF-beta-mediated Inhibition of Primary and Transformed Hepatocyte Growth. Hepatology 2010 published on line on Apr 6, 2010, DOI 10.1002/hep 23703.

Han C, Lim C, Li GY, et al. Transgenic expression of of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure. J. Immunol. 2008, 181(11):8027-8035.

Han C, Lim K, Xu LH, et al. Regulation of Wnt/beta-catenin pathway by cPLA2alpha-mediated PPARdelta activation. J. Cell. Biochem 2008, 105 (2): 534-545.

Han C, Demetris AJ, Stolz D, et al. Modulation of Stat-3 activation by the cPLA2alpha and COX-2 controlled PGE2 signaling pathway. J. Biol. Chem. 2006, 281(34):24831-24846.

Han C and Wu T. Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. J. Biol. Chem. 2005, 280(25):24053-24063.

Han C, Demetris AJ, Liu Y, et al. TGF-beta activates cPLA2alpha-mediated PGE2/EP1 and PPAR-gamma/Smad signaling pathways in human liver cancer cells: a novel mechanism for subversion of TGF-beta-induced mitoinhibition. J. Biol. Chem. 2004, 279(43): 44344-44354.

Han C, Leng J, Demetris AJ, et al. Cyclooxygenase-2 promotes human cholangiocarcinoma cell growth: evidence for cyclooxygenase-2 independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest. Cancer Res. 2004, 64:1369-1376.

Han C, Demetris AJ, Michalopoulos GK, et al. PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21waf1/cip1 pathway. Hepatology 2003, 38:167-177.

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5263 medsch@tulane.edu