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The People of Tulane Cancer Center Research


Brian RowanBrian G. Rowan, Ph.D.
Associate Professor and Interim Chair, Structural & Cellular Biology (Anatomy)
Gerald & Flora Jo Mansfield Piltz Endowed Professor of Cancer Research
Tulane Cancer Center Program Member

Contact Information
Email: browan@tulane.edu
Phone: 504-988-1365
Address: 1430 Tulane Ave., Box SL-49, New Orleans, LA 70112

Biographical Narrative

Dr. Rowan received his Ph.D. in pharmacology and cancer therapeutics from the State University of New York at Buffalo in 1994. His thesis research involved Structural and Functional Characterization of Glucocorticoid Receptors in the P1798 Mouse Lymphosarcoma. From 1994 - 2000, he was a postdoctoral fellow in Molecular and Cellular Biology at Baylor College of Medicine in Houston, TX. In 2000, he joined the faculty of the Medical College of Ohio in Toledo as an assistant professor in the Biochemistry and Molecular Biology Department. Dr. Rowan has several awards to his credit, including the Sigma Xi Award for Excellence in Research, 1988, and the American Association for Cancer Research Young Investigator Scholar Award, 1999 and 2000. He is a reviewer for numerous medical journals, including Cancer Research, Endocrinology, Journal of Biological Chemistry, Molecular Cell, Molecular and Cellular Biology, Molecular Endocrinology, PNAS and Steroids, and is a member of the American Association for Cancer Research and the Endocrine Society. Dr. Rowan joined the Tulane University Health Sciences Center faculty as Associate Professor in the Department of Structural and Cellular Biology in 2005. His research seeks to define the molecular mechanisms governing steroid receptor action in normal and disease states of female reproductive tissues with the aim of developing new therapies and improving existing therapies for breast cancer, gynecological malignancies, contraception and postmenopausal hormone replacement therapy. Additional research areas include experimental therapeutics for estrogen receptor negative breast cancer, circadian regulation of estrogen receptor function, and adipocyte stem cells in reconstructive surgery and soft tissue repair.

Representative Publications

  1. Human adipose-derived Stromal/stem Cells induce functional CD4+CD25+FoxP3+CD127- regulatory T cells under low oxygen culture. Trivia P. Frazier, James McLachlan, Jeffrey M. Gimble, Hugh A. Tucker, and Brian G. Rowan. 2013 (under revision to Stem Cells and Development).
  2. Disseminated breast cancer cells acquire a highly malignant and aggressive metastatic phenotype during metastatic latency in the bone. Carolyn G. Marsden, Mary Jo Wright, Latonya Carrier, Krzysztof Moroz, and Brian G. Rowan (2012). PLoS One. 2012;7(11):e47587. PMID:23173031
  3. Peptidomimetic Src/pretubulin inhibitor KX-01 (KX2-391) as a single agent and in combination with paclitaxel suppresses growth and metastasis in human ER/PR/HER2-negative tumor xenografts in NUDE mice. Muralidharan Anbalagan, Alaa Ali, Ryan Jones, Carolyn Marsden, Mei Sheng, Latonya Carrier, Yahoa Bu, David Hangauer and Brian G. Rowan (2012). Mol Cancer Ther. 2012 Sep;11(9):1936-47. PMID: 22784709
  4. Stable Inhibition of Specific Estrogen Receptor α (ERα) Phosphorylation Confers Increased Growth, Migration/Invasion, and Disruption of Estradiol Signaling in MCF-7 Breast Cancer Cells. Huderson BP, Duplessis TT, Williams CC, Seger HC, Marsden CG, Pouey KJ, Hill SM, Rowan BG. Endocrinology. 2012 153(9):4144-59. PMID: 22733972
  5. Subcellular localization of total and activated Src kinase in African American and Caucasian breast cancer. Anbalagan M, Moroz K, Ali A, Carrier L, Glodowski S, Rowan BG. PLoS One. 2012;7(3):e33017. Epub 2012 Mar 22. PMID: 22457730
  6. Post-translational modifications of nuclear receptors and human disease. Anbalagan M, Huderson B, Murphy L, Rowan BG. Nucl Recept Signal. 2012;10:e001. Epub 2012 Feb 27. Review. PMID: 22438791
  7. Phosphorylation of Estrogen Receptor α at serine 118 directs recruitment of promoter complexes and gene-specific transcription. Duplessis TT, Williams CC, Hill SM, Rowan BG. Endocrinology. 2011 Jun;152(6):2517-26. Epub 2011 Apr 19. PMID: 21505052
  8. Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2. Williams CC, Basu A, El-Gharbawy A, Carrier LM, Smith CL, Rowan BG. BMC Biochem. 2009 Dec 31;10:36. PMID: 20043841
  9. The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity. Shah YM, Rowan BG. Mol Endocrinol. 2005 Mar;19(3):732-48. Epub 2004 Nov 4. PMID: 15528270
  10. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Desouki MM, Rowan BG. Clin Cancer Res. 2004 Jan 15;10(2):546-55. PMID: 14760076

 

1430 Tulane Ave, New Orleans, LA 70112 504-988-5187 medsch@tulane.edu